#oreader

Prognostic factors, treatment goals and clinical endpoints in pediatric pulmonary arterial hypertension Mark-Jan Ploegstra Pulmonale arteriële hypertensie (PAH) is een progressieve levensbedreigende ziekte van de longslagaders en wordt geïntroduceerd in Hoofdstuk 1 van dit proefschrift. Bij PAH zorgt de toegenomen bloeddruk in het longvaatbed voor een overbelasting van de rechter hartkamer, wat leidt tot hartfalen van de rechter hartkamer en uiteindelijk tot de dood. Ondanks grote stappen die de afgelopen decennia zijn gemaakt in de behandelmogelijkheden voor volwassenen, is PAH op de kinderleeftijd nog steeds een verwoestende ongeneeslijke ziekte. De sterftecijfers zijn vooral bij kinderen onbevredigend, en dienen te worden verbeterd. https://graphik-buro.nl/epub/markjanploegstra/ #proefschrift #drukwerk #drukken #epub #ebook #digital #publication #dissertatie #dissertation #phd #university #layout #opmaak #design #promovendi #promovendus #ontwerp #print #offset #oreader #pdf #proefschriften #artikel #vormgeving #typography #typografie #letterkunde #grafisch #graphicdesign #graphic

Medication Adherence In Children With Asthma Erwin Vasbinder Asthma is a highly prevalent chronic disease in children and is associated with impairment of quality of life and considerable healthcare use and costs. Many interventions for improving medication adherence have been studied, but the effect on medication adherence were generally small and varied between adherence measures. Only few studies have reported effects on both adherence and treatment outcomes. This thesis aims to investigate opportunities for identifying and reducing non-adherence to ICS in children with asthma in The Netherlands. The research questions were: What is the clinical relevance of non-adherence to ICS? What is the role of ethnicity as a risk-factor for non-adherence? Can Real Time Medication Monitoring with tailored SMS-reminders improve adherence to ICS, asthma control, asthma-related quality of life and the risk of asthma exacerbations? What is the role of asthma self-management by children in daily life? Are patient-reported adherence and refill-adherence suitable methods for identifying children who are non-adherent to ICS? https://graphik-buro.nl/epub/erwinvasbinder/ #proefschrift #drukwerk #drukken #epub #ebook #digital #publication #dissertatie #dissertation #phd #university #layout #opmaak #design #promovendi #promovendus #ontwerp #print #offset #oreader #pdf #proefschriften #artikel #vormgeving #typography #typografie #letterkunde #grafisch #graphicdesign #graphic

Unloading the osteoarthritic knee: osteotomy and joint distraction Jan Ton van der Woude In the young and active population results after knee replacement are less satisfactory with higher rates of revision due to mechanical, aseptic loosening. Therefore, in case of persisting, painful, conservative treatment-resistant knee osteoarthritis at relative young age, alternative, joint preserving, treatments strategies are a necessity. In this population the surgical treatment should focus on reversing the mechanical factors associated with the development and progression of knee osteoarthritis. An option in this respect is (temporarily) unloading the knee joint. Depending on the severity of the osteoarthritis (unicompartmental or bicompartmental) and malalignment, unloading of the knee joint is possible by performing an osteotomy (partial unloading) or by knee joint distraction (temporarily unloading). Therefore, this thesis aimed to improve the knowledge regarding knee joint preserving treatments, such as valgus-producing distal femoral osteotomy (DFO) and knee joint distraction (KJD). In this way a better understanding of what the optimal treatment will be in relatively young patients with conservative treatment-resistant knee osteoarthritis may be found. https://graphik-buro.nl/epub/jantonvanderwoude/ #proefschrift #drukwerk #drukken #epub #ebook #digital #publication #dissertatie #dissertation #phd #university #layout #opmaak #design #promovendi #promovendus #ontwerp #print #offset #oreader #pdf #proefschriften #artikel #vormgeving #typography #typografie #letterkunde #grafisch #graphicdesign #graphic

Mycoplasma pneumoniae: Bacterial genetic variation and colonization of the respiratory tract of children E. Spuesens M. pneumoniae is regarded as a common cause of community acquired pneumonia. We posed the hypothesis that M. pneumoniae is able to colonize the human respiratory tract and, assuming that our hypothesis could be confirmed, we also set out to study whether possible asymptomatic carriage could be distinguished from infection. In the first part the findings of bacterial genetic variation are described. We describe that M. pneumoniae subtype-1 and subtype-2 represent genetically distinct lineages with a high potential for variation by homologous DNA recombination. The second part describes the prevalence of M. pneumoniae detected by PCR, which is just as high in asymptomatic children as in symptomatic children but changes over time and season. The strains found in asymptomatic and symptomatic children do not seem to differ genetically. M. pneumoniae macrolide resistant strains have not been identified in the Netherlands. Finally we discuss the consequences of our findings on M. pneumoniae colonization and bacterial genetic variation. We discuss that diagnostic tests for an alleged M. pneumoniae infection should be interpreted with caution and we question whether a presumed M. pneumoniae infection should always result in antibiotic treatment. https://graphik-buro.nl/epub/emielspuesens #proefschrift #drukwerk #drukken #epub #ebook #digital #publication #dissertatie #dissertation #phd #university #layout #opmaak #design #promovendi #promovendus #ontwerp #print #offset #oreader #pdf #proefschriften #artikel #vormgeving #typography #typografie #letterkunde #grafisch #graphicdesign #graphic

Pathophysiology and Management of Hemostatic Alterations in Cirrhosis and Liver Transplantation F. Arshad Changes in the hemostatic system frequently occur in patients with advancing chronic liver disease, and as a consequence patients with chronic liver disease may suffer from both bleeding- and thrombotic complications. The aim of this thesis was to investigate and summarize the hemostatic function in patients with chronic liver disease prior to, during, and after orthotopic liver transplantation (OLT), and to provide insight into old and new hemostatic agents that might be helpful to decrease morbidity and mortality related to the hemostatic derangements in these patients. https://graphik-buro.nl/epub/freehaarshad/ #proefschrift #drukwerk #drukken #epub #ebook #digital #publication #dissertatie #dissertation #phd #university #layout #opmaak #design #promovendi #promovendus #ontwerp #print #offset #oreader #pdf #proefschriften #artikel #vormgeving #typography #typografie #letterkunde #grafisch #graphicdesign #graphic

Treatment of thumb carpometacarpal osteoarthritis; quo vadis? A. Spaans The unique prehensile ability of the human hand is largely due to the biomechanical function of its complex first carpometacarpal joint. This makes the thumb the most important digit of the hand. The unique demands placed on the thumb regarding mobility, stability and transmission of force make it prone to degenerative changes. Thumb carpometacarpal joint osteoarthritis is a common and debilitating problem for the patient and a challenge to manage for primary care providers, hand therapists and hand surgeons. In this thesis treatment principles and options are discussed and evaluated to provide insight in the current knowledge of this rapidly evolving field. https://graphik-buro.nl/epub/annespaans #proefschrift #drukwerk #drukken #epub #ebook #digital #publication #dissertatie #dissertation #phd #university #layout #opmaak #design #promovendi #promovendus #ontwerp #print #offset #oreader #pdf #proefschriften #artikel #vormgeving #typography #typografie #letterkunde #grafisch #graphicdesign #graphic

The role of the blood-brain barrier in drug resistance and central neurotoxicity F. Froklage Efflux transporters at the blood-brain barrier, such as P-glycoprotein (P-gp), transport potential toxic substances from the brain to the blood and thereby serve to protect the brain. However dysfunctioning of these efflux transporters may occur. In the case of P-gp upregulation, this may lead to pharmacoresistance. In contrast, decreased P-gp functioning may lead to central neurotoxicity. A first step towards understanding more about these mechanisms was to ‘image’ P-gp. Femke Froklage and colleagues decided to tackle this challenge. Will P-gp let itself be imaged? What were the obstacles? And did they succeed in what they were aiming at? By reading this book you can follow their scientific journey. https://graphik-buro.nl/epub/femkefroklage #proefschrift #drukwerk #drukken #epub #ebook #digital #publication #dissertatie #dissertation #phd #university #layout #opmaak #design #promovendi #promovendus #ontwerp #print #offset #oreader #pdf #proefschriften #artikel #vormgeving #typography #typografie #letterkunde #grafisch #graphicdesign #graphic

CLINICAL, PATHOLOGICAL AND MOLECULAR PROGNOSTIC FACTORS IN COLORECTAL CANCER JEROEN VOGELAAR De afgelopen decennia is er door vooruitgang in de chirurgie, radiotherapie en chemotherapie veel progressie geboekt in de behandeling van het colorectaal carcinoom (CRC). De prognose van alle stadia CRC zijn verbeterd onder andere door verbeterde operatieve technieken, pre-operatieve voorbereiding, agressieve benadering van metastasen en verbetering in (neo-) adjuvante therapie. Zo hebben pre-operatieve radiotherapie en de totale mesorectale excisie (TME) het percentage lokaal recidief van endeldarmkanker drastisch verlaagd en heeft adjuvante chemotherapie de overleving van stadium III coloncarcinoom doen toenemen. https://graphik-buro.nl/epub/jvogelaar #proefschrift #drukwerk #drukken #epub #ebook #digital #publication #dissertatie #dissertation #phd #university #layout #opmaak #design #promovendi #promovendus #ontwerp #print #offset #oreader #pdf #proefschriften #artikel #vormgeving #typography #typografie #letterkunde #grafisch #graphicdesign #graphic