#naprosyn

NAPROSYN

Brand Names: Naprosyn, EC-Naprosyn

Generic Available

Common Dosage Forms:

Tablets (Naprosyn): 250 mg, 375 mg, 500 mg

Delayed-release, enteric-coated tablets (EC-Naprosyn): 375 mg, 500 mg

Suspension: 125 mg/5 mL

FDA Indications:

Mild to moderate pain, primary dysmenorrhea, acute tendinitis, and bursitis (delayed-release tablets are not recommended for initial treatment of acute pain because the absorption of naproxen is delayed compared to absorption from other naproxen-containing products): 500 mg initially followed by 250 mg every 6-8 hours, as needed.

Rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis: 250-500 mg twice a day.

Acute gout: 750 mg initially followed by 250 mg every 8 hours until attack is under control.

Not recommended for use in pediatrics.

Monitor: RFT

Pharmacology/Pharmacokinetics: Naproxen’s mechanism of action is probably due to inhibition of cyclooxygenase resulting in a decreased biosynthesis of prostaglandins. Naproxen achieves an analgesic action slightly later than naproxen sodium. Peak plasma levels are reached in 2-4 hours with a half-life of 13 hours. Protein binding to albumin equals 99%. Metabolism and unchanged drug is excreted in the urine.

Drug Interactions: May increase the pharmacological effects of oral anticoagulants, lithium, and methotrexate. Do not use with other nonsteroidal anti-inflammatory agents.

Contraindications/Precautions: Contraindicated in patients hypersensitive to nonsteroidal anti-inflammatory agents. Use with caution in patients with renal impairment, hypertension, fluid retention, heart failure, bleeding disorders or a peptic ulcer, or in the elderly. NSAIDS MAY CAUSE AN INCREASED RISK OF SERIOUS CARDIOVASCULAR THROMBOTIC EVENTS, MYOCARDIAL INFARCTION, AND STROKE. NSAIDS HAVE BEEN INVOLVED IN RARE CASES OF GI BLEEDING INCIDENTS. Pregnancy Category B.

Adverse Effects: Shortness of breath, indigestion, tinnitus, edema, itching, constipation, dizziness, drowsiness, headache, nausea, and vomiting.

Patient Consultation:

May require up to 2 weeks to see noticeable improvement in arthritic conditions.

Take on an empty stomach for better absorption, may take with food to reduce GI upset.

Concurrent ingestion of alcohol may increase ulcerogenic effect.

Avoid aspirin or products containing aspirin without first consulting a physician.

May cause drowsiness. Use caution when operating machinery or when mental alertness is required.

Store in a cool, dry place away from sunlight and children.

To maintain the integrity of enteric coating, the delayed-release tablets should not be broken, chewed, or crushed during ingestion.

If a dose is missed, take it as soon as possible. If it is closer to the time of your next dose than the dose you missed, skip the missed dose and return to your dosing schedule.

Naprosyn Market Research

Executive Summary:

The 'Global and Chinese Naprosyn Industry, 2011-2021 Market Research Report' is a professional and in-depth study on the current state of the global Naprosyn industry with a focus on the Chinese market. The report provides key statistics on the market status of the Naprosyn manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.Firstly, the report provides a basic overview of the industry including its definition, applications and manufacturing technology. Then, the report explores the international and Chinese major industry players in detail.

Complete Report Details @  Naprosyn Market Research

In this part, the report presents the company profile, product specifications, capacity, production value, and 2011-2016 market shares for each company. Through the statistical analysis, the report depicts the global and Chinese total market of Naprosyn industry including capacity, production, production value, cost/profit, supply/demand and Chinese import/export. The total market is further divided by company, by country, and by application/type for the competitive landscape analysis. The report then estimates 2016-2021 market development trends of Naprosyn industry. Analysis of upstream raw materials, downstream demand, and current market dynamics is also carried out. In the end, the report makes some important proposals for a new project of Naprosyn Industry before evaluating its feasibility. Overall, the report provides an in-depth insight of 2011-2021 global and Chinese Naprosyn industry covering all important parameters.

For more information or any query mail at [email protected]

Table of Contents

Chapter One Introduction of Naprosyn Industry

    1.1 Brief Introduction of Naprosyn

    1.2 Development of Naprosyn Industry

    1.3 Status of Naprosyn Industry

Chapter Two Manufacturing Technology of Naprosyn

    2.1 Development of Naprosyn Manufacturing Technology

    2.2 Analysis of Naprosyn Manufacturing Technology

    2.3 Trends of Naprosyn Manufacturing Technology

…..

Chapter Five Market Status of Naprosyn Industry

    5.1 Market Competition of Naprosyn Industry by Company

    5.2 Market Competition of Naprosyn Industry by Country (USA, EU, Japan, Chinese etc.)

    5.3 Market Analysis of Naprosyn Consumption by Application/Type

Chapter Six 2016-2021 Market Forecast of Global and Chinese Naprosyn Industry

    6.1 2016-2021 Global and Chinese Capacity, Production, and Production Value of Naprosyn

    6.2 2016-2021 Naprosyn Industry Cost and Profit Estimation

    6.3 2016-2021 Global and Chinese Market Share of Naprosyn

    6.4 2016-2021 Global and Chinese Supply and Consumption of Naprosyn

    6.5 2016-2021 Chinese Import and Export of Naprosyn

Chapter Seven Analysis of Naprosyn Industry Chain

    7.1 Industry Chain Structure

    7.2 Upstream Raw Materials

    7.3 Downstream Industry

Chapter Eight Global and Chinese Economic Impact on Naprosyn Industry

    8.1 Global and Chinese Macroeconomic Environment Analysis

      8.1.1 Global Macroeconomic Analysis

      8.1.2 Chinese Macroeconomic Analysis

    8.2 Global and Chinese Macroeconomic Environment Development Trend

      8.2.1 Global Macroeconomic Outlook

      8.2.2 Chinese Macroeconomic Outlook

    8.3 Effects to Naprosyn Industry

Chapter Nine Market Dynamics of Naprosyn Industry

    9.1 Naprosyn Industry News

    9.2 Naprosyn Industry Development Challenges

    9.3 Naprosyn Industry Development Opportunities

……..CONTINUED

CONTACT US:

NORAH TRENT

Partner Relations & Marketing Manager

[email protected]

Ph: +1-646-845-9349 (US)

The release form and composition.

   One tablet contains 250 mg or naproxen, in packing of 30 tablets. Suspension in 5 mL contain)! 125 mg of naproxen, in 100 ml flask. One suppository contains 500 mg of naproxen, in the package 10 suppositories. The drug is manufactured by «KRKA» (Slovenia), in co-operation with the company «Syntex» (Switzerland).

Mode of action.

   Non-steroidal anti-rheumatic agent with anti-inflammatory, analgesic and resistant to heat reducing effect. Anti-inflammatory, analgesic and antipyretic effects Naprosyn is a consequence ingibp ing prostaglandin synthesis. The most pronounced is the anti-inflammatory and analgesic effect, antipyretic effect can be compared with the effect of acetylsalicylic acid.

Indications.

   Inflammatory and degenerative rheumatic diseases of rheumatoid arthritis, ankylosing spondylitis, arg roses, extra-articular rheumatism and pain syndromes of the musculoskeletal system. The drug is used in the treatment of pain after childbirth or surgery, with headache or toothache, and also at different attack rates "s oral and traumatic lesions of the soft tissues in those cases where it is necessary to achieve protype inflammatory or analgesic effect. When treating children over one year of the drug can be used as an analgesic and antipyretic agent.

Dosing and Administration.

  The therapeutic effect is achieved 500-1000 mg daily dose, in children whose weight does not pro ceeding 50 kg the daily dose purpose 10 mg / kg. Young children (1 to 5 years) administered from 1.5 to 5 mg / kg body weight per day. The drug is taken 3 times a day just for some indications (gouty arthritis, as an antipyretic and analgesic children). Naprosyn can be taken one per day. No need to morning and evening doses of medication are the same, there may be various combinations of different drugs - tablets, suppositories and suspensions. Some saw the most suitable suppositories, and for children - daily dose of 500 to 1000 mg of the drug is needed at the beginning of treatment and the treatment of the acute phase of rheumatoid arthritis, the dose is prescribed for severe symptoms, night and morning stiffness, the transition from treatment-how antirheumatic drug or another corticosteroid degenerativyh with rheumatic diseases, to a strong analgesic action for soft tissue injuries, gouty arthritis. The maintenance is 500 mg per day Naprosyn. In a fit of gouty arthritis starting dose is 750 mg Naprosyn on one pace, followed by 375 mg every 8 hours until the attack passes. In juvenile arthritis in children older than 5 years assigned Naprosyn 10 mg per 1 kg of body weight per day. Children under the age of 1 year to 5 years, the drug is prescribed as an analgesic and antipyretic

• from 2.5 to 5 mg / kg body weight 3 times per day is not more than 1 day.

contraindications.

   There is no absolute contraindications The drug should not be used during an allergic reaction to ipprosin, acute peptic ulcer and liver dysfunction, or lobes of the heart, as well as children under the age of 1 year, pregnant women during lactation.

Adverse effects.

   Sometimes it may appear such digestive dysfunction, such as pressure feeling pain in the stomach, heartburn, vomiting, and also the noise feeling in the head, dizziness. A slight burning sensation in the application of suppositories. In rare cases, allergic reactions may occur.

Warning.

   The drug is not recommended for use in gastro-intestinal bleeding in history. Naprosyn online has the ability to prolong bleeding, it must be taken into account when assigning concurrent therapy.