#m6a

LC Sciences provides a microRNA (miRNA) expression profiling service using microarrays based on our in-house-developed μParaflo® technology platform.

In recent years, RNA modifications have attracted increasing scientific interest, particularly N6-methyladenosine (m6A)—the most prevalent methylation modification observed in mRNA. Methylated RNA immunoprecipitation sequencing (MeRIP-seq or m6A-seq) is a highly effective method for detecting m6A and other post-transcriptional RNA modifications. Furthermore, this method enables genome-wide identification of m6A sites, allowing researchers to quantify modification levels across genes and perform comparative analyses between groups.

Applications

Investigation of mRNA translation and degradation

Study of embryonic development and cellular differentiation

Analysis of disease pathogenesis mechanisms

m6A RNA Sequencing (m6A-seq) Advantages

Strategic collaboration

We have partnered with a leading RNA methylation team to streamline the experimental and analytical processes.

Extensive experience

We have constructed over 10,000 m6A-Seq libraries and supported our clients in publishing more than 200 scientific papers, over half of which appeared in high-impact journals (IF > 10).

Specialist team

Our team includes experienced professionals who can assist you with experimental design, data analysis, and result interpretation.

Reliable and fast turnaround time

A dedicated project manager ensures that results are delivered within 20 business days of sample quality verification.

Research team

Ensuring the highest level of data quality and reproducibility.

Our Comprehensive Service

At LC Sciences, we offer a genome-wide microRNA expression profiling service utilizing a microarray detection system that was developed specifically for microRNA detection.  Send us your total RNA sample and we’ll perform all the necessary functions from sample QC through data analysis.  We can perform microarray analysis on a single sample to create a simple expression profile or we can hybridize two samples to the same microarray for “dual sample” analysis.  This is very useful whenever comparison of two samples is needed such as wildtype vs. mutant or samples treated in two different ways.

Our “Total RNA to Data” comprehensive service includes: Sample QC, Sample Preparation and Labeling, microRNA Detection (hybridization to a µParaflo® microfluidics chip), Array Scan and Data Extraction, and Full Data Analysis.

In about 2-3 weeks you will receive: original and processed scan images, array layout and a list of sequences, raw and processed data, a list of differentially expressed transcripts (dual sample arrays only), and a summary of the results.

A novel derivative of rhein overcomes temozolomide resistance in glioblastoma by regulating SOX9 through m6A methylation☆

🔬 Key highlights:

Temozolomide resistance mechanisms in glioblastoma

Novel rhein derivative and its therapeutic potential

Regulation of SOX9 through m6A methylation

Future directions in precision oncology

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New Gene Regulation Essential for Proper Brain Functioning

Researchers from the Johannes Gutenberg University Mainz (JGU) and Institute of Molecular Biology (IMB) have discovered a new way of gene regulation that is deemed important for nervous system activity. This gene regulation involves a chemical alteration on RNA known as m6A which plays a significant role in determining whether flies would be males or females. In this study, the importance of RNA…