Treatment of the Ear Giant Keratoacanthoma with Topical Imiquimod-Juniper Publishers
Authored by Hong-Duo Chen
Keratoacanthoma (KA) is an epidermal neoplasma with rapid growth and severe local destruction. Owing to its similarities to squamous cell carcinoma, complete surgical excision is mainly recommended. Topical imiquimod is an ideal option for the problematic sites and cosmetic demands. Here we report a giant case of KA on a rare anatomical location, and fully recorded the disease process. The patient was treated successfully with topical imiquimod.
Keywords: Keratoacanthoma; Imiquimod
What’s already known about this topic?
Keratoacanthoma (KA) is an epidermal neoplasma with rapid growth and local destruction. Topical imiquimod is an ideal option for the problematic sites and cosmetic demands. Â
What does this study add?
 • The patient presented with a giant KA lesions on the left anthelix, which was a rare anatomical location and not recorded in the medical literatures.
 • The tumor process was fully described in our study.
 • The tumor was successfully treated with topical imiquimod, which provides a valuable reference for the treatment of some malignant skin tumors with the topical immune regulatory therapy
Keratoacanthoma (KA) is an epidermal neoplasma with rapid growth and spontaneous regression tendency. Owing to its similarities to squamous cell carcinoma (SCC) and severe local destruction, complete surgical excision is mainly recommended. However, nonsurgical options are required in consideration of the tumor size, problematic sites, and cosmetic demands [1,2]. Here, we report a giant KA case on the rare location successfully treated with topical imiquimod.
A 87-year-old Chinese man presented to our clinic with rapidly growing large ear tumor for 6 months duration. The skin examination revealed a well-circumscribed, measuring about 3×3cm, black-crusted crateriform tumor on the left ear. The lesion started as little papule with centre keratin plug suspect as virus wart, no treatment was given. The tumor rapidly grew to 3cm in diameter; and the centre crust and ulceration with basis proliferation were observed at presentation (Figure1 A-D).
The previous history included prostate cancer and colon tumor with surgery treatment. Lab assay revealed mild decreased hemoglobins; hepatorenal functions were within normal limits. No enlarged superficial lymph node was palpable. Head-neck and thoracic computer tomography were carried out with negative results. Histopathological examination exhibited the regular crateriform architecture, with marked hyperkeratosis, acanthosis and papillomatosis; the atypia of squamous cells were found (Figure 2). The diagnosis of KA was confirmed. We treated him with the imiquimod cream once every 2 days. The tumor remarkably decreased in size after 6 week treatment. After 12 weeks, the lesion was almost completely cleared leaving mild crust. (Figure1E-F) Maintained treatment was applied for another 4 weeks.
Keratoacanthoma (KA) is a benign epidermal neoplasma with local destruction. The aetiopathogenesis still remains uncertain. The complete process of the disease commonly lasts 4-9 months [2] KA is generally considered relevance to previous skin trauma, such as laser treatment and scars, and probably having relations to systemic immunosuppressive therapy [3-5]. Since the histological features of KA bears a close resemblance to typical SCC, and no befitting criterion can be used to distinguish with sufficient sensitivity and specificity, complete surgical excision was usually nominated for most cases [6]. However, surgery approach has its limitations. KA commonly grows on face and neck, oversized tumor and the problematic sites pose special difficulties for complete excision considering the cosmetic and functional need. When underlying malignancies have to be taken into account, alternative therapies are broadly researched all along.
A research indicated that topical imiquimod cream, topical 5-fluorouracil, intralesional 5FU, intralesional methotrexate, intralesional bleomycin, and intralesional interferon all showed high clearance rates when applied in KA [1] Among them topical imiquimod (once daily, 3 to 4 days per week, 12 weeks duration) even showed 100% clearance rate in the treatment of KA. Previous reports proved the same curative effects while applying topical imiquimod to KA lesions with the usage above [7,8]. Imiquimod, known as an immune-response modifier, can interact with Toll-like receptor 7 on antigen-presenting dendritic cells. After activating both the innate and acquired immune systems with the expression of varieties of cytokines, it can subsequently destruct tumor cells [9]. Along with therapeutic process, side effect as restricted severe inflammatory reactions seems unavoidable [7-10]. In our case, the tumor was located at the left anthelix, which was rare in previous reports. Considering the problematic anatomical location and tumor size, topical imiquimod was given. After about 12-week treatment, the tumor was cleared. Another 4 weeks maintained treatment was given for the high risk of malignancy.
In summary, we report and add to the medical literature a unique case of giant keratoacanthoma of anthelix with fully recorded disease process, which was successfully treated with topical imiquimod. Our research provides a valuable reference for the treatment of some malignant skin tumors with the immunoregulatory therapy of topical imqumoid.
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