#zika

I loved this pilot and I’m glad it’s getting the love it deserves 💥💥💥 please watch “pretty please I don’t want to be a magical girl”

loserguardian ("self-proclaimed loser" x "star guardian: guardian of the stars"; also based on fanart)

moonshine (Zira is moon-themed/stars are meant to shine)

aikazira (just their names mushed together)

cheesedonuts (Aika likes cheese/Zira's hair kinda looks like mochi donuts... I just made this one up lmao)

To start off, we have everyone’s favorite disease: COVID-19

So, this is one of the designs where I could actually find the artist explanation, so I will be including that information plus a couple things I noticed and how I think it fits the disease. So let’s start with to crown. The reason for the inclusion of the crown is the reflect the name coronavirus, corona being the Latin word for crown. The face is partially obscured because of COVID’s tendency to hide itself. The bean bag chair that they are sitting on has many protrusions signifying the spike proteins. The different digital devices represent how the world went virtual during the pandemic and the news channels behind them represent the media’s freak out when COVID was at its height. The floor has an outline of the world because everywhere was affected by the pandemic. Also, if you look closely, they are wearing little Covid earrings.

Next up, we got Zika:

I could not find an official artist statement for this design, so take my explanation with a grain of salt. So first off the red waist band reminds me of the red stripe that goes down the abdomen of the mosquito species that spreads Zika after it has fed. Also, the white markings on the black are also a characteristic of this species of mosquito. In fact, the design is the stripes on the chest look like the markings these mosquitoes have on their back. She presents female because it’s the female mosquitoes that bite and spread diseases. Her sleeves look like mosquito wings once again a reference to mosquitoes being the primary vectors of Zika. The area behind her has palm fronds to represent that Zika is a disease typically found in tropical climates.

Next up we have: Hansen’s Disease (aka Leprosy)

This is one where I could find the artist statement due to it being a pretty recent one, however, I will say that at least the translation was a bit lacking in describing the reasoning of every detail. She is a mask maker because leprosy changes how people perceive those who are infected but it is something that can easily be removed with modern antibiotics. She has different accessories like the lion and crocodile headpiece that implicate the divine involvement because leprosy has been historically thought to be a punishment of the gods. The scales on her arm look like an allusion to the scaling pattern scars that those with leprosy would develop.

Next up: Rubella

After a lot of digging I found the official profile for this design but it didn’t really explain the design choices so we are going to do more analysis on my end. So the pomegranate and the red dots represent the red rashes that come with rubella infections. The glasses I assume are to show how Rubella can lead to Congenital Rubella Syndrome (CRS) which can occur in children if their mother had rubella while pregnant. One of the symptoms that comes with CRS is cataracts.

Next up: the plague

I found the explanation on this and it just confirmed my own suspicions for certain design choices. So her design is very focused on death and mysticism because of how the Black Plague led to a lot of cultural focus on these two ideas. Behind her are old coins because of the economic impact the plague had on the civilizations of its time. The references to death are the skeletal pattern on her dress, and the scythe behind her and on her belt. The references to mysticism include the tarot cards she is holding and the crosses on her hat. On the tarot cards are designs referencing the three different forms the plague takes (bubonic, septicemic, and pneumonic) as well as a posey which was used to try to ward of the plague in old times. On her hat is also a collection of plague doctor masks which is pretty self explanatory as to how that connects.

Next up: Ebola

I couldn’t find the official explanation for this disease, so this is mostly speculation based on my analysis. Her outfit is red because of the hemorrhaging that comes with the disease. Specifically he lips are red because one of the more unique characteristics of Ebola is hiccuping up blood. The accessories seem to be inspired by central and western african traditional jewelry. There appear to be tribal masks on the necklace, I am not well versed in African art unfortunately, so any deeper meaning of these accessories are unfortunately lost on me. There are bats on the headdress because of bats being the natural host of Ebola. Her design is rather demonic because Ebola was so terrible for the areas affected, that people thought it could be caused be some great evil. The skulls are because of the extremely high death rate that comes with ebola. The leaves and fruits shown come from the African jungles which is typically where Ebola outbreaks start.

Next up: Novel Influenza A Virus Infections

I actually found the artist explanation for this design! As a disease closely associated with birds, there are many elements linked to birds. There are many bird shadows, the hair that looks like feathers, and the beak shaped mask, feathers on his tie and a feather tattoo on right arm, and the “H-N” pin (H and N proteins of the influenza virus).

Next up: Dengue Fever

Another one with an artist statement! Since only female mosquitoes bite, the character is set as a female. Her dark red lips represent mosquito’s instinct to bite, and she is holding a poisonous thornapple flower. She has mosquito wings tattooed on her back and thornapple flower tattooed on her arm. I have spent a long time looking into how the thornapple flower relates to dengue, but I haven’t had a lot of luck. From what I have seen is that the roots, seeds, and leaves are used in some traditional medicines, including treatments for malaria, but I have not had luck finding how it is connected to Dengue specifically.

Next up: Japanese Encephalitis

I found the artist statement for this disease as well. The disease is visualized into three characters that form a pop group, with their names reflecting the 3 main Culex mosquito species that spread Japanese encephalitis in Taiwan, which are Culex tritaeniorhynchus (Three), Culex annulus (Ring), and Culex fuscocephala (Shiro). They wear black and white, like the colors of the Culex mosquitoes. Red accessories represent their love for blood. I don’t have much to add outside of the artist explanation.

Last one for now is: Rabies

Stealth Hazard

Zika virus infection can spread between cells of the developing placenta through tunnelling nanotubes, evading immune recognition – the mechanism is reliant on the virus's NS1 protein

Read the published research article here

Image from work by Rafael T. Michita and colleagues

Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA

Image originally published with a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0)

Published in Nature Communications, February 2025