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Positive Affirmations
"Kratom is just a word."
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"Hygiene is just a word."
"Hepatotoxicity is just a word."
"Girlfriend is just a word."
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"Shame is just a word."
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Study sheds light on the link between gut microbiota, isoflavones, and geniposide hepatotoxicity
A recent study published in Engineering has shed light on the relationship between gut microbiota, isoflavones, and geniposide hepatotoxicity. Geniposide, a key ingredient in Fructus gardeniae used in many traditional Chinese medicine prescriptions, has shown potential hepatotoxic effects due to its metabolite genipin. This research focused on exploring whether isoflavones in soy products, with…
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The aim of this study is to contribute to the management of drug-induced hepatitis through the valorization of Zea mays beards. The aqueous extract of Zea mays beards was obtained by decoction. Secondary metabolites were searched for by the colorimetric method and minerals were searched for by the calcination – mineralization method. The study of the acute toxicity of the aqueous extract of Zea mays beards was conducted orally, following the OECD Guideline 423. Hepatotoxicity was induced by gavage with paracetamol 1000 mg on 7 days. The results of the study indicate that the aqueous extract of Zea mays beards contains secondary metabolites, including alkaloids, saponins, polyphenols, flavonoids, tannins, quinones and minerals including chromium, potassium, iron, zinc, magnesium and copper. The aqueous extract of Zea mays beards is not toxic orally up to a dose of 5000 mg/kg body weight and corrected abnormally high levels of alanine aminotransferase and aspartate aminotransferase. This normalization of alanine aminotransferase and aspartate aminotransferase levels would be linked to the flavonoids and zinc present in said extract. This study reveals the hepatoprotective effect of the aqueous extract of Zea mays beards.
Gallic acid protects against cadmium chloride-induced alterations in Wistar rats via the antioxidant defense mechanism
Gallic acid protects against cadmium chloride-induced alterations in Wistar rats via the antioxidant defense mechanism
Image: wikimedia Article published in the Journal of Pharmacy & Pharmacognosy Research 9(5): 668-676, 2021. Oluwafemi Adeleke Ojo1,2*, Damilare Rotimi2, Ayomide Emmanuel Bright2, Omowumi Titilola Kayode3, Adebola Busola Ojo4, Omokolade Oluwaseyi Alejolowo1,2, Basiru Olaitan Ajiboye5,6, Olarewaju M Oluba1,2 1Landmark University SDG 03 (Good Health and Well Being Research Group),…
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Hepatotoxic Effects of the Methanol Extract of Senna Siemea in Wister Rats - Crimson Publishers
Hepatotoxic Effects of the Methanol Extract of Senna Siemea in Wister Rats by Eze SOO* in Crimson Publishers: Peer Reviewed Material Science Journals
Senna siamea is a plant used in the tradomedicinal practice for the treatment of malaria. Despite its efficacy, there is no scientific information concerning the safety of the plant extract on the liver hence, the study evaluated the effect of the methanol extract on liver function enzymes in wistar albino rats. Thirty two rats weighing between 180-210g were randomly grouped into four of 8 rats each. Group 1(control group) received normal saline, while groups 2, 3 and 4 received orally 100, 200 and 400mg/kg/body weight of the extract. Two animals were sacrificed on weeks 1, 2, 3 and 4 respectively and both blood and organ samples were collected.
For more Open access journals in Crimson Publishers please click on below link https://crimsonpublishersresearch.com/
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A STUDY ON THE EFFICIENCY OF PHYLLANTHUS NIRURI IN AMELIORATING THE DRUG INDUCED OXIDATIVE STRESS IN Oreochromis mossambicus AND ITS COMPARISON WITH A HERBAL FORMULA LIV 52 | UTTAR PRADESH JOURNAL OF ZOOLOGY
In Oreochromis mossambicus, the hepatoprotective and antioxidant potential of Phyllanthus niruri and Liv.52 in alleviating paracetamol-induced hepatotoxicity is compared. When fish were exposed to various amounts of paracetamol, the TBA value increased while the total protein content decreased. The addition of Phyllanthus niruri and Liv.52 to the feed reduces reactive oxygen species (ROS), resulting in a lower TBA value, suggesting less lipid peroxidation. It's possible that the lower protein levels in these groups are due to increased protein utilisation for active metabolism and development. Fish fed Phyllanthus niruri had a lower TBA value than paracetamol-exposed animals, but fish fed commercially grown Liv.52 had an even lower TBA value than those fed Phyllanthus niruri, meaning that Liv.52, which is a mixture of many medicinal plants, has a greater protective effect. The t test is used to statistically analyse the results. Please see the link :- https://mbimph.com/index.php/UPJOZ/article/view/1991
