Jan 23
In Situ Ca2+-Reinforced Full-Active Hydrogels for the Treatment of Rheumatoid Arthritis by Modulating the NF-κB and NLRP3 Pathways - Research
Rheumatoid arthritis (RA) tissues exhibit high levels of reactive oxygen species (ROS) and free Ca2+, which contribute to a vicious cycle of sustained inflammatory responses. This study developed an in situ Ca2+-reinforced injectable full-active HPAP hydrogel. The full-active hydrogel is formed by cross-linking phenylboronic acid-functionalized hyaluronic acid (HA-PBA) with sodium alginate (ALG)…
#arthritis#Ca2Reinforced#doi:10.1021/acsami.5c23763#FullActive#Hanmeng Liu#Hydrogels#Kang Liu#MEDLINE#Mingjing Wang#Modulating#National Center for Biotechnology Information#National Institutes of Health#National Library of Medicine#NCBI#NFκB#NIH#NLM#NLRP3#Pathways#pmid:41572504#PubMed Abstract#research#rheumatoid#Situ#Treatment
