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Foxo1 Promotes Th9 Cell Differentiation and Airway Allergy
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Induced Foxo1 Expression in Th9 Cells
To research the position of the transcription issue Foxo1 in Th9 cells, we first measured Foxo1 expression in several T helper subsets together with Th1, Th2, Th9 and Th17 cells. Naïve CD4+ T cells have been polarized in vitrounderneath the abovementioned situations for Four days and Foxo1 mRNA and protein ranges have been measured by quantitative…
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Because DLK1 is colocalized with insulin in pancreatic β-cells, we examined the role of DLK1 in insulin signaling in OBs and energy metabolism. We show that Glu-OCN specifically stimulates Dlk1 expression by the pancreas. Conversely, Dlk1-deficient (Dlk1−/− ) mice exhibited increased circulating Glu-OCN levels and increased insulin sensitivity, whereas mice overexpressing Dlk1 in OB displayed reduced insulin secretion and sensitivity due to impaired insulin signaling in OB and lowered Glu-OCN serum levels
Proposed model of DLK1 action in regulating the OCN-insulin feed-forward loop.Â
OB-secreted Glu-OCN stimulates DLK1 production by islet β-cells. DLK1 exerts a negative feedback mechanism that impairs insulin signaling–induced OCN production by OB, thus antagonizing Glu-OCN–induced hypoglycemia. P, phosphorylation.
Digestive Cells Converted into Insulin-Secreting Cells
By switching off a single gene, Columbia Medical Center scientists have converted cells from the digestive tract into insulin-secreting cells. This suggests that drug treatments might be able to convert gut cells into insulin-secreting cells.
Senior author Domenico Accili said this of this work: “People have been talking about turning one cell into another for a long time, but until now we hadn’t…
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Confocal microscopy time-lapse:Â Translocation of FOXO1-GFP from nucleus to cytoplasm following addition of insulin (Frescas et al., JBC).Â
