Top Posts Tagged with #dlk1

Nuevo marcador en sangre materna predice complicaciones del parto

Una proteína encontrada en la sangre maternal puede ser usada para desarrollar tests que determinen la salud fetal y permita toar decisiones tempranas en la elección del momento de poner fin a la gestación, de acuerdo a un estudio realizado en la Universidad Reina María de Londres, Inglaterra (QMUL).

Tests realizados en ratas y en un grupo reducido de mujeres encontraron que bajos niveles de un…

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#ciencia #complicaciones del embarazo #DLK1 #genetica #Inglaterra #nature genetics #obstetricia #POPs cambridge #tocoginecología #Universidad Reina María de Londres

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Because DLK1 is colocalized with insulin in pancreatic β-cells, we examined the role of DLK1 in insulin signaling in OBs and energy metabolism. We show that Glu-OCN specifically stimulates Dlk1 expression by the pancreas. Conversely, Dlk1-deficient (Dlk1−/− ) mice exhibited increased circulating Glu-OCN levels and increased insulin sensitivity, whereas mice overexpressing Dlk1 in OB displayed reduced insulin secretion and sensitivity due to impaired insulin signaling in OB and lowered Glu-OCN serum levels

Proposed model of DLK1 action in regulating the OCN-insulin feed-forward loop.

OB-secreted Glu-OCN stimulates DLK1 production by islet β-cells. DLK1 exerts a negative feedback mechanism that impairs insulin signaling–induced OCN production by OB, thus antagonizing Glu-OCN–induced hypoglycemia. P, phosphorylation.

#insulin #DLK1 #Pref1 #osteocalcin #FoxO1 #ATF4 #FOXO #ocn #Gprc6a #notch #FA1 #Alp #Runx2 #Irs1 #Insl3 #Cebpb #Adra1d #Gsk3β #Ptpn1 #AKT