#osteocalcin

Bone not adrenaline drives fight or flight response. Thoughts health innovators?

The fight-or-flight response, also known as the acute stress response (ASR), is a physiological reaction mediated by the sympathetic nervous system which plays a critical role in helping animals react to potentially life-threatening situations. More specifically, the adrenal glands, which sit on top of the kidneys, release a variety of hormones such as adrenaline, norepinephrine, and cortisol…

Histological analyses of orthodontic force in Cavia porcellus: Comparison between immunohistochemistry and hematoxylin-eosin

image: Flickr Article published in the J. Pharm. Pharmacogn. Res., vol. 10, no. 4, pp. 695-700, July-August 2022. DOI: https://doi.org/10.56499/jppres22.1363_10.4.695 Erliera Sufarnap1,3*, Syafruddin Ilyas2, Nazruddin Nazruddin3, Deddi P. Putra4, Aditya Rachmawati3 1Doctorate Program, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia. 2Department of Biology, Faculty of…

BEWARE-Fight or Flight May Be in Our Bones

Halloween ghosts and goblins may be our early warning that THE holiday season is here, raising our stress levels in preparation for gift shopping, cooking, cleaning, relatives, financial pressure . . .

The flight or fight response, our body’s way to prepare us to combat danger and keep us alive:

You breathe faster

Your heart rate increases

Your blood pressure increases

Your pupils dilate

The…

Vitamin K2 supports bone health by modifying osteocalcin, a protein involved in bone formation

Proposed model of DLK1 action in regulating the OCN-insulin feed-forward loop. 

OB-secreted Glu-OCN stimulates DLK1 production by islet β-cells. DLK1 exerts a negative feedback mechanism that impairs insulin signaling–induced OCN production by OB, thus antagonizing Glu-OCN–induced hypoglycemia. P, phosphorylation.

Gestational Diabetes Affects the Quality of Umbilical Cord Mesenchymal Stromal Cells

The laboratories of Drs. Jene Choi and Chong Jai Kim from the University of Ulsan College of Medicine in Seoul, South Korea have collaboratively shown that the therapeutic quality of umbilical cord mesenchymal stem cells is profoundly affected by gestational diabetes. Their work was published in a recent issue of the journal Stem Cells and Developmentand has profound implications for regenerative…