Letâs all take a minute to talk about why adrenal fatigue is not real and why you likely have HPA axis dysfunctionâŚ.your adrenal glands donât just say f*ck you and stop making cortisol, but they will inactive it to make you listen and slow you down aka stress less, sleep more, stop being so much of super spaz ââ- Cortisol is made from cholesterol in the Zona fasciculata layer of the adrenal cortex, however, 80-90% of cortisol is bound to cortisol-binding globulin (CBG), with only 1-3% of cortisol being free and un-bound ______ While you make cortisol first, different glands (liver, kidney, colon) can keep it as cortisol or convert it into cortisone (aka the biologically inactive form) through the enzyme 11-beta-hydroxysteroiddehydrogenase (11bHSD) ââ- The amount of cortisol made and the amount of free cortisol available can be very different, hence why âAdrenal fatigueâ is not a real thing ______ Higher levels of metabolized cortisol (compared to free cortisol) are often seen in obesity, as the adrenal glands have to keep up with the creation and excretion of cortisol, making cortisol production rather high _____ In those with low thyroid functioning, you might see the metabolism (or clearance) of cortisol through the liver to be slow, which can result in free cortisol to increase and lower metabolized cortisol _____ This is why we test for metabolized cortisol and free cortisol markers as cortisol is metabolized into 5-alpha-Tetrahydrocortisol (5a-THF) and 5-beta-Tetrahydrocortisol (5b-THF) and cortisone is metabolized into 5-beta-Tetrahydrocortisone (5b-THE) _____ Metabolized cortisol= how much cortisol is being made all together and being cleared through the liver ______ Free cortisol= how much cortisol is FREE to bind to receptors ______ Testing for the metabolites of cortisol can also tell us about the activity of 11b-HSD types I and II, which is the enzyme that controls the activation and inactivation (to cortisone) of cortisol _____ #briannaapproved #stress #cortisol #DUTCHtest #adrenalfatigue #adrenals #recoveringsuperspaz #broscience #adaptogens (at Brianna Max Diorio Nutrition, Fitness, Lifestyle) https://www.instagram.com/p/BsOGsqbHwHZ/?utm_source=ig_tumblr_share&igshid=1ufo105u44dvo
