#hormones

Research supports a shift toward estradiol monotherapy for trans women, using estradiol alone without additional testosterone blockers.

A groundbreaking study published in the Journal of the Endocrine Society reveals that injectable estradiol may significantly improve hormone therapy outcomes for trans women, Pink News reports.

Researchers analyzed data from 29 patients who switched from traditional estradiol forms (gels or tablets) to weekly injections over a 15-month period. Despite receiving a lower average dose (3.7 mg vs. 4.3 mg), all participants experienced a dramatic reduction in testosterone levels, while maintaining stable estrogen levels.

The study also challenges the efficacy of Spironolactone, a commonly prescribed anti-androgen.

From the research paper Injectable Estradiol Dosing Regimens in Transgender and Nonbinary Adults Listed as Male at Birth: Results The average estradiol dose decreased from 4.3 to 3.7 mg weekly (P < .001) during the study period with a final on-treatment estradiol level of 248 pg/mL. All individuals achieved a testosterone level of less than 50 ng/dL during the study period. The average initial on-treatment testosterone level was not significantly different from average final on-treatment measurement of 24.0 mg/dL (P = .95). Spironolactone use at study initiation was not associated with a lower initial on-treatment testosterone level, though it was associated with a lower estradiol level of 285 pg/dL compared to 427 pg/dL for those on estradiol monotherapy (P = .017). Conclusion Lower doses of injectable estradiol can achieve therapeutic estradiol levels with excellent testosterone suppression. Spironolactone was not associated with additional testosterone suppression and may result in lower estradiol levels.

You were a late bloomer during your teenage years and that's fine. You had a late growth spurt, so what?

But now you were old enough to have that second puberty in your early 20s. Yay for you.

Your hips and breasts seemed to look more womanly, your voice had dropped a bit again, and your face had definitely grown into its more mature features. Not in the bad way, the sexy way, you know? You looked full of life and hot.

Anyways, You had just gotten home from work, taken a shower and had cuddled up with your pillows in bed, doomscrolling on some app to pass the time.

As some people do, you got bored of that and just decided to go on some porn sites to masturbate before falling asleep. It helped you go to lala land quicker.

You had your hand underneath the blanket and were about to shove it under your panties, a video starting to play with some woman with a fat ass and a guy with a PHAT cock but a sudden noise made you jolt up and tug the covers up to your chin, fumbling with your phone to turn off the video.

"What the hell?" you rolled over to turn on your light... and there he was, a tall man like looking being with four arms, a large maw on his stomach grinning, baby pink hair and four red eyes, looking right down at you with an unimpressed expression.

Wait, where were his clothes? Oh, no, he had on pants. Phew.

You blurted out the first thing that came to mind.

"Are you the puberty fairy?"

The only fairy thing about him was the pink hair, maybe.

Sukuna's scowl deepened, narrowing his eyes as he bent down to glare at you, a deep tone leaving his face mouth, looking offended, the second maw looking amused, its tongue lolling out.

"The fuck did you just call me?"

You cowered a bit, eyes doe and hands gripping the bedsheets. "The... puberty fairy?"

"Puberty FAIRY? I'm the damn hormone monster! I'm not a fairy."

"Hormone monster? What's that?"

The beast of a man looked like he was about to lunge at you. But he took a deep breath, standing back up and one of his upper arms pinched his nose, the bottom two settling on his hips.

"Lady, you're going through puberty. I'm your hormone monster, to teach you... shit." He growled, mostly to himself, contemplating his life choices.

"But i'm not 15 or something! I'm a grown woman." You frowned, getting a bit defensive, but still hiding behind the blanket.

"Yeah, well but i was sent here because you're changing, now shut the fuck up and accept it. What were you watching though? Looked lame as shit, let me put you on something better." He reached for your phone, clearly just wanting to help find better goon material.

"Oh... like, we're gonna have sex now?" You asked, looking a bit too excited, getting the wrong idea when he got closer.

One of his upper eyes twitched.

"Do i look like an incubus?"

"...I mean, you're pretty hot-"

Sukuna tilted his chin up, looking up at the ceiling as if gathering his last bits of patience.

"Fine."

You blinked and you were flipped around, blanket ripped away from your hands, face buried in the pillows as a heavy weight dipped the bed down behind you.

"H..huh? For real?"

"Shut up, pest. Unless you want me to leave."

The sound of fabric shifting... and then TWO heavy, hot things flopped down on your ass. You had clearly been expecting only one!

You gasped, trying to look back but a hand the size of your whole damn scalp gripped the back of your hair and pushed it back down into the pillows.

"Stay put."

Yoon's notes: I WANT A HORMONE MONSTER TOO Reupload from my old account @/yoonsucksalot ! (i redid it a bit hihihi) HUGE MEGA DRIPPING WET THANKS TO @liliklei @yorikae !!!