#drugresistant

A potentially deadly type of fungus that is almost untreatable continues to pose severe threats to healthcare facilities across the U.S., a new government study found. Limited time: Save 25% on NBC News subscription Get exclusive reporting, live Q&As and ad-free reading. Candida auris, or C. auris, is a yeast that can cause serious illness in people with weakened immune systems. Since the…

Chen et al. identify the natural product butyrolactol A as an inhibitor of the phospholipid flippase Apt1-Cdc50, which it locks in a nonfunctional state. By disrupting membrane homeostasis and enhancing drug uptake, butyrolactol A restores echinocandin efficacy against intrinsically resistant fungal pathogens, including Cryptococcus and Candida auris. Read more about this post… Credits:…

The rates of bloodstream infections caused by drug-resistant bacteria will increase substantially across Europe in the next five years, driven largely by aging populations, according to a new paper published November 4th in the open-access journal PLOS Medicine by Gwenan Knight of the London School of Hygiene and Tropical Medicine, UK, and colleagues. Antimicrobial resistance (AMR) is a global…

The top candidates they discovered are structurally distinct from any existing antibiotics, and they appear to work by novel mechanisms that disrupt bacterial cell membranes. This makes them less vulnerable to antibiotic resistance, a growing problem: It is estimated that drug-­resistant bacterial infections cause nearly 5 million deaths per year worldwide. Now that they can generate and evaluate…

It is estimated that one-third of the 50 million people worldwide with epilepsy are resistant to anti-seizure medications. These patients, having drug-resistant epilepsy, have limited treatment options beyond surgery to control their seizures. Even surgical interventions become difficult in many of these patients due to challenges in pinpointing the anatomical source of their seizures, such as…

New research reveals how probiotic supplementation helps fragile preterm babies build healthier gut microbiomes and lowers the spread of dangerous, drug-resistant bacteria in neonatal intensive care units. Study: Impact of early life antibiotic and probiotic treatment on gut microbiome and resistome of very-low-birth-weight preterm infants. Image credit: Iryna Inshyna/Shutterstock.com A new study…

With help from artificial intelligence, MIT researchers have designed novel antibiotics that can combat two hard-to-treat infections: drug-resistant Neisseria gonorrhoeae and multi-drug-resistant Staphylococcus aureus (MRSA). Using generative AI algorithms, the research team designed more than 36 million possible compounds and computationally screened them for antimicrobial properties. The top…

A landmark study presented today at ESCMID Global 2025 has revealed that over 3 million children worldwide lost their lives in 2022 due to antimicrobial resistance (AMR)-related infections. The study underscores the urgent need for both regional and global strategies to control paediatric AMR, particularly in high-burden areas such as South-East Asia and Africa. AMR poses a critical threat to…