#conserved

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are clinically heterogeneous malignancies whose biology and microenvironmental organization remain poorly understood. Here, we integrated single-nucleus multiomic (snRNA-seq and snATAC-seq) and spatial transcriptomic profiling across 38 well-differentiated pancreatic (pNET) and small-intestinal (siNET) tumors to define conserved malignant…

Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are clinically heterogeneous malignancies whose biology and microenvironmental organization remain poorly understood. Here, we integrated single-nucleus multiomic (snRNA-seq and snATAC-seq) and spatial transcriptomic profiling across 38 well-differentiated pancreatic (pNET) and small-intestinal (siNET) tumors to define conserved malignant…

Science, Volume 389, Issue 6759, Page 501-507, July 2025. Summary Without knowing the specific content of the Science issue mentioned, it’s impossible to provide a truly accurate summary. However, I can offer a general summary based on what we can infer: A research article published in the July 2025 issue of Science (Volume 389, Issue 6759, pages 501-507) likely presents findings from a…