STING signals to NF-κB from late endolysosomal compartments using IRF3 as an adaptor - New Study
Nature Immunology, Published online: 19 September 2025; doi:10.1038/s41590-025-02283-8 Here the authors show how the DNA-sensing cGAS–STING pathway activates NF-κB and inflammatory gene expression with delayed kinetics via post-Golgi endolysosomal signaling. Summary A Nature Immunology article published September 19, 2025, reveals a novel mechanism of the cGAS-STING pathway. The authors…





















