Allogeneic Stem Cell Transplant Curative for Many Cancers

Allogeneic Stem Cell Transplant Curative for Many Cancers

by Jeffrey Dach MD

One of the secrets of mainstream oncology is they actually have a cure for Cancer.  I was somewhat surprised and astonished to discover mainsteam oncology has been using allogeneic stem cell tranplant to cure many hematologic cancers for many years now.   This is not widely known. Above image: Stem Cell Transplant…

Cellectis' Allogeneic CAR-T Potential Still Justifies A 'Buy'

Engineering TCR-preserved allogeneic CAR-T cells: leveraging cancer immune evasion principles to establish T-cell tolerance Summary Engineering allogeneic CAR-T cells that retain their T cell receptor (TCR) could overcome challenges of current CAR-T therapies. By understanding how cancer cells evade immune responses, researchers aim to engineer CAR-T cells that induce tolerance. This involves…

Donor or Autologous Stem Cells: Which Is Right?

When someone needs a stem cell transplant, there are two options: donor stem cells (Allogeneic) or autologous stem cells. Donor stem cells are from another person, most often an exact match like a sibling. These are often used to treat diseases like leukemia. The plus is that they may be able to battle the disease better, but there can be rejection or side effects.

Autologous stem cells are harvested from the patient’s own body. They are commonly transplanted for such cancers as lymphoma. Since they are one’s own cells, there is less likelihood of rejection. But they may not fight the disease that much. The choice of either relies on the individual’s condition, medical condition, and the doctor’s advice. Both have strengths and weaknesses.

Author Correction: Allogeneic NK cells with a bispecific innate cell engager in refractory relapsed lymphoma: a phase 1 trial Summary In a phase 1 trial, researchers explored the safety and efficacy of allogeneic natural killer (NK) cells combined with a bispecific innate cell engager (BIKE) in patients with relapsed or refractory lymphoma. This author correction likely addresses an error or…