Pseudomembranous enterocolitis
oral vancomycin= treatment; but if ileus present = can add IV metronidazole or switch to rectal vancomycin
if the WBC > 20,000, lactate > 2.3 mg/dL, toxic megacolon (+), and severe ileus present = options include subtotal colectomy or diverting loop ileostomy with colonic lavage
*note IV vancomycin is not excreted into the colon and is therefore not effective against C.difficile colitis; however, oral vancomycin is effective
cancer should be ruled out by proper PE including proctosigmoidoscopic exam= even if benign process
typically bleed (internal)= can be treated with rubber band ligation
painful (external)= may be surgically removed if conservative treatment fails
anoscopy should be done to rule out rectal cancer
young women, exquisite pain with defecation and blood streaks covering the stools
fear of pain so intense that they avoid bowel movements and get constipated
refuse proper physical examination, and may require anesthesia
tight sphincter main problem, rectal exam may show posterior mucosal tear of anus and skin tag
in additional to stool softeners and sits baths, topical lidocaine and nifedipine areas for management
sitz baths increase blood flow to injured mucosa
initial treatment= high fiber diet and increased fluid intake
surgical intervention like lateral sphincterotomy, fissure excision indicated for fissures that are refractory to medical management
gradual dilation of sphincter can provide wider aperture for passage of stool and interrupt spasm but leads to fecal incontinence and possible recurrent fissures
affects the anal area commonly
starts with fissure fistula or small ulceration but diagnosis suspected if area fails to heal and gets worse after surgical interventions
note: anal area typically heals well because has good blood supply= failure to do so means crohnâs
Surgery never the right answer for crohn
fistula= can be drained; diagnosis confirmed with endoscopic or radiographic studies
endoscopy shows focal ulcerations adjacent to normal mucosa- cobbelstoning with skip areas of disease (microscopy shows non caveating granulomas)
radiography shows strictures and towel wall thickening
tx: 5-ASA drugs, corticosteroids, antibiotics, azathioprine, anti-TNF therapies
complications: fistulas, strictures (bowel obstruction), abscesses
biopsy shows mucosal and submucosal inflammation and crypt abscesses
endoscopic findings include: erythema, friable mucosa with pseudo polyps, Â involvementt of rectosigmoid, continuous colonic involvement
complications: toxic megacolon, primary sclerosis cholangitis, colorectal cancer, erythema nodosum, pyoderma gangrenosum, spondyloarthritis (all these can be present with Crohnâs)
increased risk of colorectal cancer and therefore colonoscopy with mucosal sampling should be offered to patients with UC beginning 8 years after initial diagnosis and repeated every 1-2 years thereafter
aka perirectal abscess presents with exquisite perirectal pain enabling the patient to sit down or have bowel movements
classic findings of abscess, lateral to anus  and between rectum and ischial tuberosity
incison and drainage needed and cancer should be ruled out by proper examination during procedure
if diabetic, horrible necrotizing soft tissue infection may follow, watch closely= may require debridement
can develop in people who had ischiorectal abscess drained
epithelial migration from anal crypts (where abscess originated) and from perineal skin (where drainage was done) form a permanent tract
fecal soiling and perineal discomfort
PE shows opening lateral to anus and a cordlike tract may be felt and discharge amy be expressed
fungating mass grows out of anus, mets to inguinal nodes often
diagnose with biopsy, treatment with nigro chemoradiation protocol, followed by surgery if residual tumor