Empress of Forever by Max Gladstone

Vivian Liao is a highly successful innovator, but she may have bitten off more than she can chew and fears the government may be coming for her. As she goes into hiding, she attempts to pull off one last stunt that could fix everything - but something goes wrong, and suddenly Vivian finds herself waking up in the far future, under attack by an army of robots in space. Hoping to find her way back home, Vivian must assemble a crew of dangerous outlaws to help her hunt down the Empress of Forever, the all-powerful entity who pulled her into the future. Lesbian main character.

The Mimicking of Known Successes by Malka Older

Novella. On the outpost of a human colony by Jupiter, a man has gone missing. On the case to find him - and figure out why he disappeared in the first place - is enigmatic investigator Mossa. Her search leads her to the colony's university, and with it, her ex-girlfriend Pleiti, expert on Earth's pre-collapse ecosystem. Together they come to realize that the case is much larger than just a missing man, and could decide the outcome of humanity's very future. Sapphic.

My Heart is Human by Reese Hogan

Nine years ago, all complex technology was made illegal. This complicates life for Joel, young transgender single father, as a bionic just uploaded itself into his brain without consent. Scared of losing his daughter, Joel tries to keep the bionic secret while using it to fix his life, but things quickly get more complicated as the bionic gains more and more control of his body. A bit simplistic in writing style but makes a lot of cool parallels of bodily autonomy to Joel’s experiences as a transman. M/M romance.

The Vanished Birds by Simon Jimenez*

A strange child lands on an isolated planet, scaring its inhabitants into handing him over into the hands of Nia Amani. As captain of a transport ship, Nia is not only the planet's only contact with the outside world, she is also a woman out of time, years compressing into months as she travels through space at high speeds. Now responsible for a child who doesn't speak and in a galaxy that wishes them ill, she must rethink exactly what she wants to do with her life, and what she's prepared to give up. Features multiple major queer characters.

The Abyss Surrounds Us (The Abyss Surrounds Us duology) by Emily Skrutskie

Young Adult. Tumblr classic back in the day! Cassandra Leung's family are keepers of sea monsters, genetically engineered and trained to protect ships from pirates. On her first solo mission, Cas finds herself kidnapped by pirates seeking to obtain their own monster. Now they need her help to train it. As Cas seeks to regain her freedom, she must also reckon with unfortunate growing feelings for one of the pirates keeping her under guard. Sapphic.

Ancestral Night (White space series) by Elizabeth Bear

Haimey Dz is part of a three-man salvage crew in space (one of the crew being the sentient spaceship himself). When the small crew comes across a derelict ship that proves the scene of a horrible crime, they must go on the run as they seek to uncover a conspiracy that involves both ancient secrets older than humanity itself, and Haimey's own hidden past. On their tail is a dangerous space pirate, convinced that Haimey is the key to it all. Lesbian main character.

Ancillary Justice (Imperial Radch) by Ann Leckie*

A space opera in which sentient spaceships can walk the ground in stolen human bodies, so called ancillaries. One of these ancillaries, the sole survivor after the complete destruction of her ship and crew, is one the hunt for revenge against the most powerful woman in the empire. This series does very cool things with gender!

The City We Became by N.K. Jemisin

Five New Yorkers find themselves experiencing strangness as the city itself begins to wake up. They are its soul, its avatars and its protectors, and now they must keep it safe as it wakes as something alien and monstrous attempts to kill it before it's even fully alive. Mix of sci-fi, supernatural, and lovecraftian horror. Multiple pov characters of varying queer identities.

Gideon the Ninth (The Locked Tomb series) by Tamsyn Muir*

Gideon, raised as a swordswoman by unfriendly nuns, would rather run away and make her own life, but her services are needed. The Reverend Daughter, Gideon's childhood nemesis, has been invited to a trial to win a place as an immortal by the Emperor's side, and she's in need of a bodyguard. Listen, if you’re on tumblr I probably don’t need to explain this book to you. Trust me when I say it’s exactly as good as people claim. Humorous and spooky but also absolutely gut wrenching and clever with a lot of political commentary. There are also, indeed, lesbian necromancers in space.

A Big Ship at the Edge of the Universe (Salvagers trilogy) by Alechia Dow

In a universe run on science and magic working hand in hand, Boots Elsworth makes a living selling fake treasure maps and Nilah Brio is a racer. When one of Boots' maps turns out to be more real than expected and Nilah has to go on the run after having been framed for a murder, the two find themselves on the same spaceship, working with Boots' old captain to find the rumored treasure and reveal the conspiracy its hiding before the people hunting them catch up. Features a main f/f relationship.

The Company of Death by Elisa Hansen*

A wild mix of genres, where a zombie apocalypse has struck and vampires gather up humans to keep their food source from going extinct, a robot travels across America with a young man she’s tasked to keep safe, and former-vampire-hunter-recent-zombie Emily teams up with Death himself to stop the apocalypse. Features bi and ace characters! Bonus rec: the author also runs the youtube channel Maven of the Eventide, where she talks about various vampire media. Check it out!

Light from Uncommon Stars by Ryka Aoki

Shizuka Satomi is a violin master who made a deal with a devil, and who must now save her soul by delivering the souls of her students in place of her own. Lan Tran is a mother and a refugee of an alien war, hiding on Earth with her children in a donut shop. Katrina Nguyen is a trangender runaway and violin player, in the need of a mentor. As their paths cross, their lives change forever. I would categorize this as cozy, however it does also deal with some pretty heavy themes.

The Summer Prince by Alaya Dawn Johnson*

Young adult. Young artist June Costa lives in Palmares Tres, a beautiful, matriarchal city relying heavily on tradition, one of which is the Summer King. The most recent Summer King is Enki, a bold boy and fellow artist. With him at her side, June seeks to finally find fame and recognition through her art, breaking through the generational divide of her home. But growing close to Enki is dangerous, because he, like all Summer Kings, is destined to die. While the main relationship is m/f, it features a worldbuilding where bisexuality is the norm, which is portrayed in its major characters.

The Gilded Abyss by Rebecca Thorne

Nix Marr is a soldier and damned good at it, but that doesn't prepare her for her next mission: bodyguard for Subarch Kessandra, beloved royal and Nix's bitter ex, as she ventures into the underwater city of Fall to seek the cause of a bloody murder spree and a possible deadly contagion. But Kessandra has enemies, the answers she seeks marking her as a possible threat for the nation's rulers. On their way in an isolated and enclosed underwater ship toward Fall, the contagion catches up, and Nix will have to put her hurt feelings aside if the two are to arrive alive. Sci-fi with flavors of horror and the supernatural.

Adaptation (Adaptation duology) by Malinda Lo

Young adult. Strangeness is afoot: all over America, birds are hurling themselves against airplanes and causing crashes. As flights are canceled and travelers stranded, Reese and her debate partner and longtime crush David are forced to head home by car. Accident strikes, and the two wake in a military hospital with no memory of the last month. Returning home, strangeness follows the two, especially as Reese encounters the mysterious and beautiful Amber Gray, who may know more than she lets on. Features a bisexual love triangle.

Lizard Radio by Pat Schmatz

Young adult. Fifteen-year-old Kivali, abandoned at birth and adopted by the nonconformist artist Sheila, has as a girl in boys clothes never fit in with the other kids. Sheila has always been supportive, until she one day sends Kivali off to CropCamp. While Kivali chafes at the strict rules of the camp, she also finds herself making friends, and maybe more, for the first time. Strange coming of age story, featuring exploration of gender and sexuality in a dystopian setting.

Isle of Broken Years by Jane Fletcher

Young spanish noblewoman Catalina thinks she’s done for when the ship she’s traveling on is attacked by pirates and she’s captured. Things gets worse when the entire crew is stranded on an inhospitable island where time works strangely, dangerous monsters terrorize the woods and something alien stops them from leaving. Strong Lost vibes. Lesbian romance. Admittedly quite indulgent but very fun and creative.

All Systems Red (The Murderbot Diaries) by Marta Wells*

After having hacked its own governor module, SecUnit uses its small amount of new freedom to secretly download and watch as much media as it can between doing its job guarding humans. But when the scientists it’s been charged with keeping safe come under attack, it must make a choice about whether to continue keeping its freedom secret or risk it all to save them. The series features both novellas and full length novels, and balances humor with scathing critique of capitalism. While it can be debated whether SecUnit counts as agender, asexual and aromantic, as it is a robot (I leave this up to individual judgmenet), however the series also has a diverse cast overall.

The Quiet at the End of the World by Lauren James*

Young adult. After the spread of a global virus causing infertility, teenagers Lowrie and Shen are now the youngest humans alive as the adults around them race to find a cure. As they investigate the ruins of the world, the two come across records from the past, of how grief stricken people turned to raising artificial children in apps and how these 'children’ developed, and through these records the two learn of their history. Bisexual main character.

Chain-Gang All-Stars by Nana Kwame Adjei-Brenyah*

In a near future America, inmates on death row or with life sentences in private prisons can choose to participate in death matches for entertainment. If they survive long enough - a rare case indeed - they regain their freedom. Among these prisoners are Loretta Thurwar and Hamara “Hurricane Staxxx” Stacker, partners behind the scenes and close to the deadline of a possible release - if only they can survive for long enough. As the game continues to be stacked against them and protests mount outside, two women fight for love, freedom, and their own humanity. Chain-Gang All-Stars is bleak and unflinching as well as genuinely hopeful in its portrayal of a dark but all to real possible future. Sapphic.

The Disasters by M.K. England

A decade ago, the massive ship House of Wisdom was abandoned in orbit after its entire crew was killed in an outbreak in a matter of hours. Now, Zahra and her people hope to claim the ship as their own by kidnapping the sole survivor to gain access to its systems. But the danger of the House of Wisdom is far from gone. Horror, no major romance but has a major gay character.

Nax Hall may be a hotshot pilot, but that doesn't stop him from being expelled from the prestigious Ellis Station Academy in less than 24 hours. But as he's to be transported back to Earth alongside other failed students, the school is viciously attacked. Nax and the three other students only barely escape, and are left as the only witnesses - and the perfect scapegoats. Now they must go on the run together and find a way to clear their names. Bisexual main character.

Dust (Jacob's Ladder series) by Elizabeth Bear

In a dying spaceship, orbiting an equally dying sun, noblewoman Perceval waits for her own gruesome death. Having been captured by an opposing house, her wings severed and life forfeit, Perceval’s execution is imminent - until a young servant charged with her care proves to be Perceval’s long lost sister. To stop a war between houses likely to doom them all, the two flee together across a crumbling, dangerous spaceship. At its core waits Jacob Dust, god and angel, all that remains of what the ship once was. And he wants Perceval. Sapphic and asexual characters, however be prepared for kinda fucked up relationships.

Under Fortunate Stars by Ren Hutchings

Two ships have gotten stuck in a rift in space, isolated outside of time. One of them is the Jonah, a ship dodging a generations long war against an alien species, carrying a small crew of smugglers, an unintended passenger, and a hijacker. The other ship is the Gallion, which arrived from 150 years in the future carrying an alien ambassador - and whose crew is awestruck at meeting the heroes of the Jonah, known to have ended the war. As the two crews struggle to understand each other's timelines, they must also work together to leave the rift before they're stranded forever. Multiple queer characters, however the main romance plotlines are m/f.

One Last Stop by Casey McQiston*

Twenty-three-year-old August has a lot to deal with. She just moved to New York, got new job at a pancake diner, and acquired several slightly chaotic roommates. So what if she likes to flirt with the pretty girl on her subway commute? But Jane turns out to be more than just a charming stranger: she's lost in time, displaced from the 70s, and unable to leave the subway. Romance with a dash of timetravel sci-fi, One Last Stop is a delightful story of love and queer community.

The Women Could Fly by Megan Giddings*

In an alternate version of our present, the witch hunt never ended. Women are constantly watched and expected to marry young so their husbands can keep an eye on them. When she was fourteen, Josephine’s mother disappeared, leveling suspicions at both mother and daughter of possible witchcraft. Now, nearly a decade and a half later, Jo, in trying to finally accept her missing mother as dead, decides to follow up on a set of seemingly nonsensical instructions left in her will. Features a bisexual lead!

Salvation Day by Kali Wallace

A decade ago, the massive ship House of Wisdom was abandoned in orbit after its entire crew was killed in an outbreak in a matter of hours. Now, Zahra and her people hope to claim the ship as their own by kidnapping the sole survivor to gain access. But the danger of the House of Wisdom is far from gone. Horror, no major romance but has a major gay character.

Alien: Echo by Mira Grant