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...One of Dr. Drayne's first utterances in the game, dripping with contempt and loathing for the yankee doodle before him. Iconic - and historical!

The good doctor here is showing his age with this oath - God's blood - which was used from the Middle Ages up to the early modern period (1500-1700). Dr. Drayne is a 1594 baby, so he would have been very familiar with this oath and unafraid to use it when suitably rattled. People in those days would curse on God or Christ's body parts rather than break the Second Commandment - not to take the Lord's name in vain oaths. In this case, it is a reference to the blood Christ spilled during his crucifixion, as well as the wine of the Eucharist. I doubt very much that Dr. Drayne cares about offending God these nights though lol.