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Game Changer & Make Some Noise

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izzy's playlists!
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@fantasmadelaciudad
my blog is a safe space for me. the rest of you are in danger i think

Anya is live and ready to show you everything. Watch her strip, dance, and perform exclusive shows just for you. Interact in real-time and make your fantasies come true.
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i always feel a little like a begging dog but i will not elaborate on that
When Drugs Became Available
Have you ever been writing some historical fiction and wondered "hey, I wonder if my characters would have been able to pop an ibuprofen in 1977?" Well, you're in luck, because this post is all about when common medications became available:
Acetaminophen: 1950
Albuterol: 1969 (UK) 1982 (US)
Allopurinol: 1966
Alprazolam: 1981
Amitriptyline: 1961
Amlodipine: 1990
Amoxicilin: 1972
Amphetamine/Dextroamphetamine (together as Adderall): 1996
Apixiban: 2012
Aripiprazole: 2002
Aspirin (first NSAID): 1899
Azidothymidine (first antiviral): 1987
Barbital (first barbiturate): 1903
Bupropion: 1985
Buspirone: 1986
Calcium Carbonate (TUMS): 1930
Captopril (first ACE inhibitor): 1981
Chlordiazepoxide (first benzodiazepine): 1960
Chlorothiazide (first thiazide diuretic): 1957
Chlorpromazine (first antipsychotic): 1952
Cyclobenzeprine: 1977
Diphenhydramine: 1946
Furosemide: 1959
Fluoxetine (first SSRI): 1988
Gabapentin: 1993
Glipizide: 1984
Hydrochlorothiazide: 1959
Ibuprofen: 1969 (UK) 1974 (US)
Insulin: 1923 (though many types of insulins would become available over the next century)
Imipramine (first tricyclic antidepressant): 1959
Iproniazid (first antidepressant (MAOI)): 1952
Levothyroxine: 1927 (though desiccated pork thyroid was used for the same reasons as early as 1890)
Lisinopril: 1987
Lithium: 1949
Losartan (first ARB): 1995
Lovastatin (first statin): 1987
Naproxen: 1976 (Rx) 1990 (OTC)
Nitrogen Mustard (first chemotherapy agent): early 1940's
Methotrexate: 1947
Methylphenidate: 1954
Metformin: 1957 (France) 1995 (US)
Metoprolol: 1978
Montelukast: 1998
Morphine: early 1800's
Omeprazole: 1989
Penicillin: 1945
Phenbezamine (first antihistamine): 1942
Prednisone: 1955
Propranolol (first beta blocker): 1965 (UK) 1967 (US)
Sertraline: 1990
Spironolactone: 1959
Sulfanilamide (first modern antibiotic): 1935
Tolbutamide (first oral anti-diabetic drug): 1956
Tramadol: 1977 (Germany) 1995 (US)
Trazodone: 1981
Valacyclovir: 1995
Verapamil (first calcium channel blocker): 1964
Warfarin: 1954
Zopiclone (first "Z-drug"): 1986
Someone asked for this list in date order, so here it is!
Morphine: early 1800's
Aspirin (first NSAID): 1899
Barbital (first barbiturate): 1903
Insulin: 1923 (though many types of insulins would become available over the next century)
Levothyroxine: 1927 (though desiccated pork thyroid was used for the same reasons as early as 1890)
Calcium Carbonate (TUMS): 1930
Sulfanilamide (first modern antibiotic): 1935
Nitrogen Mustard (first chemotherapy agent): early 1940's
Phenbezamine (first antihistamine): 1942
Penicillin: 1945
Diphenhydramine: 1946
Methotrexate: 1947
Lithium: 1949
Acetaminophen: 1950
Chlorpromazine (first antipsychotic): 1952
Iproniazid (first antidepressant (MAOI)): 1952
Methylphenidate: 1954
Warfarin: 1954
Prednisone: 1955
Tolbutamide (first oral anti-diabetic drug): 1956
Chlorothiazide (first thiazide diuretic): 1957
Metformin: 1957 (France) 1995 (US)
Furosemide: 1959
Hydrochlorothiazide: 1959
Spironolactone: 1959
Imipramine (first tricyclic antidepressant): 1959
Chlordiazepoxide (first benzodiazepine): 1960
Amitriptyline: 1961
Verapamil (first calcium channel blocker): 1964
Propranolol (first beta blocker): 1965 (UK) 1967 (US)
Allopurinol: 1966
Albuterol: 1969 (UK) 1982 (US)
Ibuprofen: 1969 (UK) 1974 (US)
Amoxicilin: 1972
Naproxen: 1976 (Rx) 1990 (OTC)
Cyclobenzeprine: 1977
Tramadol: 1977 (Germany) 1995 (US)
Metoprolol: 1978
Captopril (first ACE inhibitor): 1981
Trazodone: 1981
Alprazolam: 1981
Glipizide: 1984
Bupropion: 1985
Buspirone: 1986
Zopiclone (first "Z-drug"): 1986
Lovastatin (first statin): 1987
Azidothymidine (first antiviral): 1987
Lisinopril: 1987
Fluoxetine (first SSRI): 1988
Omeprazole: 1989
Amlodipine: 1990
Sertraline: 1990
Gabapentin: 1993
Losartan (first ARB): 1995
Valacyclovir: 1995
Amphetamine/Dextroamphetamine (together as Adderall): 1996
Montelukast: 1998
Aripiprazole: 2002
Apixiban: 2012
one thing abt me is that I can't recognize veneers and I can't tell when someone's hair is a wig and I can't clock fake accents even when they're done pretty badly and I'm also bad with faces. all that to say I would be insanely vulnerable to hijinks/capers
does anyone know how to get what you want when you're the type of person who avoids everything

Anya is live and ready to show you everything. Watch her strip, dance, and perform exclusive shows just for you. Interact in real-time and make your fantasies come true.
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im about to catsit next month for a (lovingly) crazy woman who is so deeply obsessed with her cat's care its touching truly. he needs insulin shots and she is telling me that shes going to send voice notes to my phone of her saying "copo! baby! its time for your insulin!" "come here handsome!" "its insulin time sweetie!" so that he feels safe getting his insulin from a stranger. im like girl i love it. i love this
she was telling me yesterday "sometimes i look at him and he looks at me and i feel like we can hear each other's thoughts. is that crazy" and i was like "no of course not"
the idea that predators and abusers are an ontological category of person, rather than everyone having the capacity to be predatory and abusive, leads to people having no regard for boundaries because they think that predation only comes from evil people ™
A Flock of issues. The post Florida Man Finds Easy Way to Stop Flock Cameras From Working Right appeared first on Mandatory.
i blocked the mcr tag like two years ago but i always know when theyre actively doing a show because i’ll get an untagged post on my dash that says something like Albuquerque has been lost to the wastes
T shirt that says “I ❤️ getting laid” & then on the back it says “to REST” with a photo of a coffin + the name & phone number for a local cemetery. Please follow for more advertising ideas

Anya is live and ready to show you everything. Watch her strip, dance, and perform exclusive shows just for you. Interact in real-time and make your fantasies come true.
Free to watch • No registration required • HD streaming
love this site
Tumblr’s one true talent is making me sick of things I’ve never seen or read or heard.
the beauty of the reflection
does anyone wanna come over and be devastated

Anya is live and ready to show you everything. Watch her strip, dance, and perform exclusive shows just for you. Interact in real-time and make your fantasies come true.
Free to watch • No registration required • HD streaming
i understand why writers keep their alien worldbuilding relatively simple for story practicality reasons but its always a lil funny to me when a sci-fi series is like "this alien species is a culture of bounty hunting warriors" like damn all of them? the whole planet? a whole planet-scale society built on bounty hunting? that seems highly impractical but i'll believe it for you bestie.
my cherios spelled out my exact address this morning but like what the gudge ever i gobbled those honey nut freaks up and licked the bowl too
someone contact my fucking lawyers