RANDOM SHIZZLE

crows have been documented holding ‘funerals’ for many years. however, researchers suggest that they may not be mourning; evidence indicates that crows may be examining the body & surrounding area for potential threats to the rest of the flock.

…….it’s a fucking autopsy and criminal investigation.

You might even call it

me: yes

*lighting appears*

me: yES

*thunders explode*

me: YES

*raining intensifies*

no fake friends, just real friends (the only ones who’ll come out to your godforsaken lighthouse to hang)

lots of stairs so u dont need a gym membership

when u look out the window and sigh mournfully it’s Cinematic Depression not just regular depression

minimum requirements: 1 large dog, 17 cable-knit sweaters, 1 mysterious but tragic past, 2 pair fingerless wool gloves

increased likelihood of mermaid encounters

effortless windswept look, complemented by soft lantern glow

Okay if you're a so-called vegan president of the gays, good for you. But stop shaming us for 'not being proud enough of who I am. I am not just bi. I am proud of other traits, like my sense of humour, bright mind or fabulous hair. I couldn't care less about myself being bi of whatever. I care about the people I would love because of that. Because that's what defines it. You just love a broader spectrum op people. Well woohoo~~

Antifreeze (ethylene glycol) seems to be quite tasty to animals. In this essay I will elaborate on why ingestion of the toxic-waste colored substance is a Very Bad Thing (seriously, this shit is luminously colorful and even comes in pink!).

Firstly, ethylene glycol can cross the blood-brain barrier (strike one) and cause euphoria, as seen with regular drinking alcohol.

Secondly, we need to look at the Alcohol Metabolism Cycle. The enzyme Alcohol Dehydrogenase features in the breakdown of almost everything ending in -ol. Yes I agree that breaking down the poison into smaller bits is a good idea, but not in this case. The problem with breaking down ethylene glycol is that the bits it gets broken into, do a lot of damage. These pieces are acids (gasp!), which cause metabolic acidosis (strike two).

Thirdly, one very specific acid made from ethylene glycol is oxalic acid, which precipitate in the kidneys in the presence of calcium, leading to renal tubular necrosis and acute renal failure. Translation: oxalic acid is a bastard that fucks up the delicate filtration system in the kidney by sticking it full of holes when it forms crystals (strike three, you’re out!).

That luminous shit is our crystals and is not supposed to be there. This is the microscopic equivalent of the Banishin’ Rock because it will kill you by taking out your kidneys. These things are difficult to remove and do untold amounts of damage to Life’s Most Fragile Organ.

So my dog/cat/domesticated dinosaur ate the blue poison juice, what do i do?

Number one: seek veterinary treatment immediately (do not message a vet blog asking for help I WILL MURDER YOU)

Number two: don’t leave antifreeze lying around, animals have a way of getting into what we least expect.

Treatment entails stopping the enzyme Alcohol Dehydrogenase from doing the dirty with the antifreeze, either through distraction or inhibition.

Inhibition: something called fomepizole can be used to inactivate Alcohol Dehydrogenase

Distraction: if caught early enough, ethanol (normal drinking alcohol) can be given as a competitive substrate. Alcohol Dehydrogenase will be kept busy by the ethanol so that the ethylene glycol can be excreted unchanged. So, vodka anyone?

Further treatment includes correction of the metabolic acidosis and control of nervous signs.

Here is the process more or less simplified and summarized:

A note from the biochemistry side: anything ending in -aze is generally accepted to be an enzyme; anything ending in -ol tends to be an alcohol.