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What kind of immortality would you rather come true?

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Menstrual blood is only recently and still poorly studied, but it is an abundant and noninvasive source of highly proliferative mesenchymal stromal ce…

Human endometrial stem cells: High-yield isolation and characterization

#stem cells #endometrial stem cells #cell therapy #cryobank #mesenchymal stromal cells #mesenchymal–epithelial transition

Regenerative medicine is now one of the few rapidly developing fields that have a great potential in significantly improving the quality of life and promoting longevity. It is highly important to create a roadmap in order to enable effective collaboration among the researchers and to multiply the future outcomes of their work. The purpose of this chart is to create an overview of the field from the scientific point of view and to list the current and future research directions in each area. The goal is to create a draft of the scientific part of the Regenerative Medicine Roadmap, which would set the guidelines for the scientists, provide research plans for the institutions and help attract potential sponsors and investors. Regenerative Medicine is divided into 5 blocks: Tissue engineering, Cell therapy, Diagnostic platforms, Healing Therapies and Supporting Technologies. The main focus of the chart lies in the Tissue Engineering and Cell Therapy parts. These parts are schematically divided into components, which in turn are described in more detail with specific research directions. Tissue Engineering comprises such areas as methods, cells for use, biomaterials, and database creation. The Cell Therapy part consists of three blocks: cell removal, regenerative capacity restoration and adding cells. Specific research directions listed provide the ground for forming research plans in each particular area. This preliminary work will help create a highly detailed plan of action in regenerative medicine.

Regenerative Medicine Roadmap 2.0

#regenerative medicine #roadmap #regeneration

Background: Diabetic foot ulcer (DFU) is one of common and serious diabetes mellitus complications that affects approximately 6% of patients with diabetes1. Besides causing pain and amputation, DFU also imposes substantial economic burden on the healthcare system. Various clinical trials and meta-analysis confirmed that cell-based therapy is capable of enhancing current DFU treatment 2,3. Our objective was to perform systematic review of the research examining the effectiveness of various stem cells (SCs) types administered by different ways in order to improve DFU healing. Methods: In total, we identified 458 relevant publications in PubMed and 438 were excluded after review of content for not meeting the inclusion criteria. Efficiency of different types of stem cells were compared according to the re-epithelialization rate calculation. Results: Overall, our findings indicate that BM-MSCs can be considered as the most effective stem cell type for the treatment of DFU (p0,05) in comparison with BM-MNCs, adipose tissue-derived stem cells (ADSCs), and peripheral blood CD34+ cells. However, BM-MSCs differ in their efficiency. Topical way of stem cells administration significantly increases the effectiveness of stem cell therapy in humans (p0,05). No significant data about allogeneic stem cells effectiveness in comparison with autologous was actually presented in articles. Cell dosage and concentration per wound area require additional data. Conclusion: We consider that differences in BM-MSCs efficiency mi...

#stem cells #systematic review #diabetic ulcer #cell therapy

BioDARPA : Biomedical Superiority

Goal: Community of scientists, medics and public persons, with the specific aim of supporting and developing the new “Biomedical DARPA” (i.e. like DARPA government agency) to protect the lives and health of millions citizens around the world.

https://www.researchgate.net/project/BioDARPA-Biomedical-Superiority

#darpa #biodarpa #superiority #immortality

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БИЛИАРНАЯ МИКРОБИОТА И ЗАБОЛЕВАНИЯ ЖЕЛЧНЫХ ПУТЕЙ

BILIARY MICROBIOTA AND BILE DUCT DISEASES

Traditionally, the biliary tract has been considered to be normally sterile, and the presence of microorganisms in bile is a marker of a pathological process. This assumption was confirmed by failure in allocation of bacterial strains from the normal bile duct. The paper provides rationale for a phenomenon of the normal biliary microbiota as a separate functional layer which protects a biliary tract from colonization by exogenous microorganisms. We revealed the potential of metagenomic data for prevention of infectious diseases, post-operative complications of reconstructive interventions including bile duct stenting and implantation the tissue-engineered structures exposed to the risks of colonization with pathogenic / exogenous microorganisms. The methods based on preserving homeostasis of normal biliary microbiota ecosystem can be used for prevention of hepatobiliary diseases and treatment of biliary tract inflammatory diseases.

For citation: Klabukov I.D., Lyundup A.V., Dyuzheva T.G., Tyakht A.V. BILIARY MICROBIOTA AND BILE DUCT DISEASES. Annals of the Russian academy of medical sciences. 2017;72(3):172-179.https://doi.org/10.15690/vramn787

#biliary #microbiota #microbiome #cholangitis #gallstone

With HARPA, advancements in biotechnology, supercomputing, big data, and A.I. would be put to work to save lives.

#harpa #biodarpa #darpa

The dramatic development of biomedical technologies inevitably raises a question of the increasing " gap " between basic biomedical discoveries and their use in clinical practice. Created in 1958 with the same purpose, DARPA has had to bridging the gap in defense technologies (mostly in rocket and radar sciences). Today we can talk about the relevance of the idea of " biomedical DARPA " (BioDARPA) as a concept of organizational design for priority research and development of emerging biotechnologies.

The dramatic progress in biomedical technologies inevitably raises a question of the increasing "gap" between basic biomedical discoveries and their use in clinical practice. Created in 1958 with the same purpose, DARPA has had to bridging the gap in defense technologies (mostly in rocket and radar sciences). Today we can talk about the relevance of the idea of "biomedical DARPA" (BioDARPA) as a concept of organizational design for priority research and development of emerging biotechnologies.

#darpa #immortality #singularity #longevity #biodarpa

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