Think about it, what's Kyomoto's role in the story? She is what got Fujino to take art seriously in middle school, and what motivated her to continue after she initially gave up. However, she's also the only thing in the story that makes Fujino wish she quit art. First, halfway through 6th grade and then later after her death. She serves as Fujino's motivator and de-motivator.

I think the scene of Fujino wishing that she never told Kyomoto to come out (that pursuing art only led to suffering) represents artists' regrets. We literally look back and see an alternate universe where Fujino never pursued art and it has a happier ending. Anyone that pursues artistic dreams will end up regretting it at some point. It's not easy, any artist will tell you that. The story is saying yes, you probably will end up healthier and more stable by giving up your dreams. Because art is suffering.

But then Fujino enters Kyomoto's room after reading the comic from the alternate reality and all of a sudden we get a montage of the happy memories and accomplishments they had pursuing their dreams together. And we realize that, everything we saw of them in the alternate 'happier' reality pales in comparison to this:

The happiest both of them look in that alternate world is when they finally meet and promise to work together someday. They loved art. They loved each other. Giving up on your dreams means missing out on all of that, and nothing in the world can replace it. Because yes art is suffering, but art is also joy and love.

And so the end of the story where Fujino goes back to work isn't her moving on. She tapes the comic strip in front of her to remind her of Kyomoto, to remind her of why she got into comics in the first place. Basically, Kyomoto IS art to Fujino. A life with her means experiencing both suffering and joy, while the life without her means having none of that.

@officialspec's amazinggg designs for spamtenna inktober day 11: human designs!