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Big pharma is failing to address our greatest medical threat
GLOBAL HEALTH SECURITY Intro: Drug-resistant infections now kill more people every year than HIV or malaria, yet only six companies remain active in antibiotic research Writing in the last few days, Professor Lord Darzi, FRS, said that big pharma is failing to tackle our greatest medical threat. The world-renowned and eminent surgeon says that every caesarean section, joint replacement, and…
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The Protein Bacteria Can’t Live Without 🧬
For decades, humanity has fought bacteria by refining the same weapons — stronger doses, modified molecules, familiar targets. Meanwhile, bacteria adapted faster than we could respond.
Now, scientists may have uncovered a fundamental vulnerability. A single protein, MurJ, acts like a molecular gatekeeper for bacterial survival. Without it, the cell wall collapses — and the bacterium dies.
What makes this discovery remarkable is that viruses already know this. Bacteriophages have independently evolved the same strategy: freezing MurJ in place. Evolution rarely repeats itself without reason.
If nature has been using this kill switch for millions of years, medicine may finally be ready to learn from it.
In this week’s edition of The Prototype, we look at using AI to find new drugs, quantum biotechnology, the ROI of generative AI and more.
💊 How AI Might Help Defeat Superbugs
In this Forbes piece from The Prototype, explore how advanced AI models are being used to accelerate drug design and potentially develop treatments for antibiotic‑resistant “superbugs” — a growing global health threat that could cause more deaths than cancer by mid‑century. Researchers trained AI on diverse genetic data to model complex biological molecules and generate novel drug candidates, many showing promising lab results. AI’s role in biotech could speed discovery and transform how we tackle resistant microbes.
“This handbook provides a comprehensive, multidisciplinary examination of antimicrobial resistance, detailing molecular mechanisms, manifestations across microbial types, and the evolutionary and structural facets of resistance.” Handbook of Antimicrobial Resistance, 1st Edition, 2017
Handbook of Antimicrobial Resistance, 1st Edition (2017) is an authoritative and expansive reference designed for researchers, clinicians, microbiologists, pharmacologists, and public health professionals confronting the global crisis of antimicrobial resistance (AMR). Edited by leading experts Matthias Götte, Albert Berghuis, Greg Matlashewski, Mark Wainberg, and Donald Sheppard, this volume synthesizes cutting-edge scientific knowledge on how microbes become resistant to antimicrobial drugs across bacterial, viral, parasitic, and fungal pathogens. The book explains the molecular mechanisms of resistance, biochemical and structural aspects of drug-microbe interactions, and evolutionary pathways that drive resistance, and discusses strategies for combating AMR in clinical and research settings. Its comprehensive coverage makes it an essential tool for understanding, teaching, and researching antimicrobial resistance in a rapidly evolving public health landscape.
click the link below to get your copy now👇👇👇:
A revolutionary phage therapy to combat 'superbugs' is here. Investigate the science, global regulatory chaos, and profound future of post-antibiotic medicine news.
🚨 BREAKING NEWS: The cure for superbugs is here, but the chaos is just beginning! 🦠
A revolutionary genetically engineered Phage Therapy, 'Phage-Slayer 7,' shows a 95% eradication rate against pan-resistant Acinetobacter. This is the dawn of the #PostAntibioticMedicine era.
But major challenges loom: How will regulators approve a 'living drug'? Who controls the production? And can we ensure global access?
Read our full report on the science, the industry shockwaves, and the high-stakes global scramble for control of the #FutureOfMedicine. 👇
#PhageTherapy #Superbugs #AMR #BiotechBreakthrough #GlobalHealth
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Real-time tracking reveals how superbugs evolve, guiding future treatments. Read more: https://www.passporthealthusa.com/2025/09/a-new-way-to-track-evolving-superbugs-in-real-time/
Exclusive: Research on burden of antibiotic resistance for 122 countries predicts dire economic and health outcomes
This sounds bad. Foreign aid cuts by the US and UK will damage efforts against antibiotic resistance.
AI turns old diabetes drug Halicin into a potent weapon against superbugs
Can an AI-repurposed diabetes drug tackle our toughest superbugs? Researchers reveal Halicin’s powerful action against deadly multidrug-resistant bacteria, except for one elusive foe. Study: Halicin: A New Approach to Antibacterial Therapy, a Promising Avenue for the Post-Antibiotic Era. Image Credit: Kateryna Kon / Shutterstock In a recent study in the journal Antibiotics, researchers…
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