#romk

im glad i got this done quickly!! i made the water look a bit like clouds but thats okay!! this ocean is very orange. is it sick..?

Kirbytober day 15: Favorite Game

I do think it’s also around this era it sorta sets in for him that like oh shit this literal child is doing all this and I know that fucked with me mentally when I was a child soldier with no support system. It’s the start of him slowly being brought back into the fray by Kirby because Kirby is like you tried to help so we’re friends again. Meta Knight does take it as an opportunity to train Kirby but mentor and eventually get to the point of yeah that’s my kid. It takes a while but he’ll get there eventually.

We've known this medical factoid since we were medical students: you can't successfully replete a potassium-depleted patient if they have low magnesium levels. But what is the mechanism by which this occurs? One possible explanation is put forth in a 2007 JASN article by Huang and Kuo. In this paper, the authors suggest that magnesium regulates the activity of ROMK, therenal outer medullary potassium channel, providing a rationale for how low Mg levels lead to low K levels. ROMK is the inwardly rectifying K channel on the apical surface of the distal nephron which is required for the backleak of K+. When there is high intracellular Mg2+, it will block the ROMK channel pore and prevent K+ from effluxing. Conversely, a low intracellular Mg2+ would allow for high ROMK efflux activity and therefore result in K+ wasting. The authors are cautious to state that additional factors (e.g., high aldosterone levels, increased Na uptake, etc) may also be required to result in clinically significant renal K+ losses.

((PLEASE READ THIS I AM DYING))

and always pissing off Boss by not getting off the Halberd both of you I swear))