#pten

Leak Less

It’s no good repairing a broken plumbing system with new pipes that leak themselves. Something like this happens when researchers investigating the mechanism behind struggling lymphatic systems – the network of microscopic pipes that drain and transport essential material in the body – add the growth-inducing molecule VEGF-C to prompt new vessel growth. As an alternative to this active encouragement, a new approach instead removed the innate brakes downstream in the regulation process. The study examined mice engineered to lack a particular protein, PTEN, in the cells lining their vessels, which freed a different key receptor for VEGF-C to step up its action. The result was an expanded network of lymphatic vessels that was less leaky and functioned better. The vessels (green in the mouse intestinal tissue shown) were long-lasting, suggesting this approach may be a better way to enhance the network.

Written by Anthony Lewis

Image from work by Raghu P. Kataru and colleagues, on the cover of Science Signaling, 10 August 2021

Department of Surgery, Division of Plastic and Reconstructive Surgery, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, USA

Image copyright held by and reproduced with permission from the AAAS

Published in Science Signaling, August 2021

Bu yazımızda özellikle köpeklerin gözleri bizlere daha masum ve tatlı görünmek için nasıl evrimleştiğine odaklanmak istiyoruz.

Köpekler, insanlarla daha iyi iletişim kurmak için göz çevresinde yeni kaslar geliştirmiştir. Köpek ve kurtların anatomisini ve davranışlarını karşılaştırmak için yapılan yeni araştırmalar, köpeklerin yüz anatomilerinin özellikle insanlarla daha iyi iletişim kurmalarını sağlamak için binlerce yıl boyunca değiştiğini göstermektedir. Köpek ve kurtların anatomisi ve davranışlarını karşılaştıran ilk…

https://neurosciencenews.com/pten-autism-15612/ Study clarifies genetic autism risk in PTEN patients