Pharma is betting big on an experimental oral drug targeting BTK that is advancing toward Phase 2 trials for food allergy, chronic hives, and multiple sclerosis.
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Pharma is betting big on an experimental oral drug targeting BTK that is advancing toward Phase 2 trials for food allergy, chronic hives, and multiple sclerosis.

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Bulk Buying Vitamins & Supplements from the UK – Essential Guide
The demand for vitamins and dietary supplements is accelerating globally, with distributors and healthcare providers increasingly turning to the UK for bulk sourcing. UK pharmacy exporters are a preferred choice due to their reputation for quality, compliance, and reliability. If you are a wholesaler, pharmacy chain, or healthcare supplier, bulk procurement ensures better margins and dependable supply.
1. Why Choose Bulk Purchases?
Bulk buying significantly reduces the cost per unit, giving businesses a competitive edge in pricing. It also helps secure steady inventory levels, ensuring that pharmacies and retailers can meet growing consumer demand without frequent stockouts.
2. Advantages of UK Supplement Exporters
UK-based exporters are renowned for adhering to international safety and quality regulations. Their offerings cover a wide spectrum, including multivitamins, probiotics, omega-3 fish oils, and herbal supplements—all of which see strong demand across Asia, the Middle East, and Africa. With the UK’s strict compliance standards, global buyers gain confidence in both product safety and authenticity.
3. Packaging & Distribution Solutions
Reputable exporters typically provide flexible bulk packaging and even private-label solutions tailored to local compliance rules. They also support logistics such as warehousing, shipping arrangements, and complete export documentation, which reduces operational challenges for international buyers.
4. Choosing Reliable Export Partners
When evaluating potential suppliers, focus on exporters with certifications such as MHRA approval or GMP compliance. A strong exporter should demonstrate capacity for large-scale distribution while consistently meeting high-quality standards.
For businesses engaged in healthcare distribution, sourcing vitamins and supplements in bulk from UK exporters is both cost-effective and dependable. By partnering with established suppliers, you gain access to top-quality products at competitive prices, ensuring steady growth in your market.
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The company was launched out of stealth last year.
The Mark Cuban Cost Plus Drugs Company (MCCPDC) is a registered pharmaceutical wholesaler and purchases drugs directly from manufacturers, bypassing middlemen to lower the price of more than 100 medications, it said in a statement.
For example, the leukemia drug imatinib is priced at $47 a month on MCCPDC compared to the $9,657 retail price.
MCCPDC CEO Alex Oshmyansky reached out to Cuban with an idea for a low-cost generic drug company in a cold email. It was launched in January last year. They were motivated in part by “Pharma Bro” Martin Shrkeli’s outrage-producing price hike of the lifesaving drug Daraprim from $13.50 to $750 per tablet while Shrkeli was CEO of Turing Pharmaceuticals. Cuban told Forbes last year the pricing for generic drugs was “ridiculous.” He said he decided to put his name on the company to “show capitalism can be compassionate and to send the message I am all in.” It’s not clear how much he had invested in the company.
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Reblog to save someone an entire paycheck, or more, on the pharmaceuticals they need.

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Drug Makers Sidestep Barriers on Pricing
If you were a physician, would you prescribe generic drugs that cost $40 a month, or Duexis, which costs $1,500 a month, where rather than sending the patient to the drugstore with a prescription, you can submit prescriptions directly to a mail-order specialty pharmacy affiliated with the drug company, and then the company deals with the insurance companies, relieving the doctor of the reimbursement hassle that might otherwise discourage them from prescribing such an expensive drug?
The pain reliever Duexis is a combination of two old drugs, the generic equivalents of Motrin and Pepcid.
If prescribed separately, the two drugs together would cost no more than $20 or $40 a month. By contrast, Duexis, which contains both in a single pill, costs about $1,500 a month.
Needless to say, many insurers do not want to pay for Duexis. Yet sales of the drug are growing rapidly, in large part because its manufacturer, Horizon Pharma, has figured out a way to circumvent efforts of insurers and pharmacists to switch patients to the generic components, or even to the over-the-counter versions.
It is called “Prescriptions Made Easy.” Instead of sending their patients to the drugstore with a prescription, doctors are urged by Horizon to submit prescriptions directly to a mail-order specialty pharmacy affiliated with the drug company. The pharmacy mails the drug to the patient and deals with the insurance companies, relieving the doctor of the reimbursement hassle that might otherwise discourage them from prescribing such an expensive drug.
Horizon is not alone. Use of specialty pharmacies seems to have become a new way of trying to keep the health system paying for high-priced drugs. Valeant Pharmaceuticals International, which has attracted government and media scrutiny for its huge price increases, does much the same thing for its dermatology products with a specialty pharmacy called Philidor Rx Services.
“They are all trying to get rid of the sticker shock of using their drugs,” said Dr. Kenneth Beer, a dermatologist in West Palm Beach, Fla. “They become the drugstore now,” he said.
He said Valeant’s program, which he had used, buffered physicians from insurers and complaints from their patients about high prices.
“It lowers one barrier to using their products,” he said.
Valeant revealed last week that it had received subpoenas from federal prosecutors in Manhattan and Massachusetts seeking information about its financial assistance programs for patients, pricing decisions and the distribution of its products. It is not clear if the probes are related in any way to Valeant’s relationship with Philidor.
Philidor, based in Hatboro, Pa., reveals little about itself on its website. It was denied a license in California in 2014 because, the state said, its application had not truthfully identified its owners and financial officers. Calls on Monday asking to speak to Philidor executives were not returned.
Valeant had said little about Philidor until Monday, when J. Michael Pearson, Valeant’s chief executive, revealed on his company’s quarterly earnings call that Valeant had purchased an option to acquire Philidor late last year. He said that Valeant consolidated Philidor’s results in its own financial reports.
Mr. Pearson also said on the call that the pricing environment had changed, and that the industry was “being aggressively sort of attacked for past pricing actions.” He said that Valeant was considering divesting the division selling neurological drugs where, he said, the biggest price increases had occurred.
He also said that in the future, price increases would be “more modest,” probably not more than 10 percent a year. Last year, he said, increases in list prices averaged 36 percent for the branded drugs sold by Valeant in the United States.
Specialty pharmacies are most known for providing patients with assistance with complex drugs, many of them requiring refrigeration and injections, for diseases like cancer, multiple sclerosis and rare genetic disorders. But the drugs dispensed through the specialty pharmacies used by Horizon and Valeant are for common ailments like arthritis pain, acne and toenail fungus.
“What was started as administering complex, costly drugs has been co-opted as a sales/marketing tool to drive the growth of minor differentiation standard retail drugs,” Ronny Gal, a pharmaceutical analyst at Bernstein, said in a note on Friday. The programs do offer advantages to patients. The drugs are delivered quickly and co-pays are subsidized. Horizon said 98 percent of patients getting Duexis have co-payments of no more than $10, less than the co-pays would be for generics in many cases.
Moreover, if the insurer refuses to pay, the patient already has the drug and the manufacturer absorbs the cost. A spokesman for Horizon said that happened for a large number of Duexis prescriptions. Still, Horizon and Valeant apparently come out ahead because enough insurers do pay.
The practice is legal, said Mr. Gal, the analyst, providing that co-pay assistance is not used for patients covered by Medicare or other federal programs. For federal programs, co-pay assistance is considered an illegal inducement to get someone to use a drug. Both Horizon and Valeant say they confine their programs to commercially insured patients.
On Horizon’s second-quarter earnings conference call in August, one analyst asked the company to discuss the positive points of the Prescriptions Made Easy program.
“I think simply, the positive is we drove over $100 million in net revenue in the second quarter, rapidly increased prescriptions,” Timothy P. Walbert, the chief executive, replied. He then said the program was “doing the right thing for patients.”
Duexis is a combination of ibuprofen, an anti-inflammatory drug, and famotidine, the ingredient in Pepcid, which is supposed to prevent the serious and even lethal gastrointestinal problems that can result from chronic use of ibuprofen or similar drugs. Both drugs are available as generics, and over the counter. Horizon says that by combining the two drugs into one pill that is taken three times a day, that makes it more likely that patients will get the benefit of the stomach protection.
Horizon has increased the price of Duexis about tenfold since the drug was introduced in late 2011. In 2013, it acquired the main competitor to Duexis, a drug called Vimovo, which is a combination of the pain reliever naproxen and the stomach protector Nexium. Horizon immediately raised the price of Vimovo about 600 percent, and has roughly doubled it again since then, so both drugs now cost about the same amount per month.
Geoff Curtis, a spokesman for Horizon, said the company needed to recoup the $100 million it invested to develop and manufacture Duexis and the $35 million it paid to acquire Vimovo. He noted the low out-of-pocket payments for patients.
Deepak Jindal, a pharmacist in Netcong, N.J., said his wife was prescribed Vimovo and he could not fill the prescription in his own store because his insurance would not cover it. But when the doctor submitted the prescription to Horizon’s program, a specialty pharmacy called Linden Care sent the drug to her for a $10 co-payment. He said he later learned that his insurance was not billed for the drug.
It has become common in the last several years for pharmaceutical companies to offer co-payment assistance to make sure patients are not deterred from using a drug by out-of-pocket costs. Once the patient uses the drug, the pharmaceutical company is paid by the insurance company. Insurers say co-pay assistance circumvents their efforts to encourage the use of cheaper drugs by setting lower co-pays for them, thereby driving up overall medical spending.
Starting this year, the nation’s two largest pharmacy benefit managers, Express Scripts and CVS Health, said they would not pay for Duexis and Vimovo.
Despite that, Horizon said in its regulatory filing for the second quarter, “with the successful adoption of our PME program by physicians,” sales volumes for Duexis increased by 72 percent in the first half of this year compared to the first half of 2014. In dollars, sales of Duexis rose 131 percent in the first half to $73.1 million. In the second quarter, 71 percent of Duexis prescriptions and 61 percent of those for Vimovo went through the Prescriptions Made Easy program.
“Horizon has perfected an innovative program to distribute its high-priced pain medications that have been actively excluded from reimbursement by a number of large payers,” Irina R. Koffler, an analyst at Mizuho Securities, wrote in a report earlier this month recommending the company’s stock. The report was titled “Outrunning Payers & Not Standing Still.”
Ms. Koffler said Horizon targeted physicians whose patients had strong commercial coverage. “Patients whose insurance covers Horizon’s medications serve to support co-pay buy-downs for patients with less generous coverage,” she wrote.
Horizon said in its regulatory filing that prescriptions filled through the program “are less likely to be subject to the efforts of traditional pharmacies to switch a physician’s intended prescription of our products to a generic or over-the-counter brand.” It said that if it were unable to get physicians to direct prescriptions to Prescriptions Made Easy, “We may experience a significant decline in Duexis and Vimovo prescriptions as a result of formulary exclusions.”
A future nurse that is kind of opposed to the use of pharmaceuticals, it’s ironic. Something I try to stray from is something that will soon be a huge part of my life. I truly believe that what you put into your body is what you put out. Using man-made chemicals for healing and treatment kind of ironic to me. (My mom is convinced I need to be on some kind of anxiety medicine, but I’ve found methods that work just as well, if not better than prescribed drugs, grant it I’m not a trained medical professional just personal experience.) We can become so dependent on something we don’t really need, feeding into a multimillion industry. In a sense we’re brain washed into thinking we need what they’re offering. Companies that are charging thousands of dollars for a product the Earth offers us for free. Draining people of just about all their assets saying, “this will prolong your life and restore (some of) your health….BUT it’s temporary and you’ll have to come back and pay us more in a few months if you want to continue to feel “better” Don’t get me wrong there is an exception to every rule, but the pharmaceutical industry’s main concern is not the customer or the patients. Their number one priority is making the money. That’s where I have the problem. Why should we be so willing to trust and hand over our money to companies that spend more on advertising the product than they do actually researching the product they’re giving us to put in our bodies? And why is it that today over 70% of Americans take prescription drugs?  Have we all of a sudden become more unhealthy and sickly than we were in previous years, if anything we should be seeing those numbers decrease, with all the advancements in technology and medicine.
I’m not saying I’m totally against the use of medicine, that’s illogical. I’m not saying we should stop taking medicine all together and heal ourselves with only herbs and minerals, but we should begin to use caution. We should only take what we absolutely need. Instead of putting so much money into the creation of artificial treatments we should spend more resources researching forest, “nature’s medicine cabinet”, taking advantage of what the Earth has to offer.  You don’t need to be treated for every little thing wrong with you. What you’ve convinced yourself to be severe stress you need prescription drugs for could be solved by some kind of meditation.Â
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