#macrolide

The fourth cassette in the Vanity box courtesy of Invivo is a great collection of varied minimal/diy styles from rock/punk to electronic, industrial and more. It was recorded in 1980 and includes one live track.

The liner notes (see scan) state side A is by Invivo and side B by Invitro. Here is a track breakdown.

Side A: B.B.B. - Invivo, like others in the Vanity Box also contributed to the Vanity Music compilation DLP. In this case this track appeared in much abbreviated form on the compilation. Repetitive drum machine either going through distortion or some other effect w/ slowly modulating synth waves and bass guitar.

Micoplasma (1983) - Low pinging rhythm with synth pulses and other sounds.

LD50 (live) - Lots of guitar, a bit of sax and some sort of live percussion. Before the sax comes in, this could just have easily been a Metabolist recording.

m.i.c. - This track segues with a gurgling synth line resembling the main guitar part from the previous one. The addition of a sax makes this a nice mood setting tune and is unfortunately a little shorter than I'd wish.

Macrolide (C H NO) - Slightly uptempo drum machine, synth and bass guitar.

Bacteroides - Drum machine and bass that sounds like a BGM or early Cabaret Voltaire outtake.

Side B: Proteus - Slow pulsing snyth with guitars that works very well.

Amoxicillin - There is a bit between this song and the previous one that I wasn't sure where it belonged. Rather than keeping these two combined I included the brief sound burst at the end of B1 and the start of B2. What starts off as Jamaican sounding music, possibly another recording morphs into drum machine, synth, sax and more. The sax here, as in all but m.i.c. is very subdued and usually deep in the mix, not in your face.

Kiebsiella - Minimal synth and bass guitar.

Micoplasma (1979) - A slowed down version of similarly titled track on the other side. Like Conrad Schnitzler in 'super slo-mo'.

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The planet we live in, the earth. In the entire universe, it is still difficult to determine whether there are other living things. The earth has long been a lonely planet. We have been searching for the universe, expecting to get signals from other living beings, expecting to know that we are not alone, and there are other lives in this deep universe. But it turned out to be counterproductive…

Common Brand Names: Zithromax

Therapeutic Class: A semisynthetic macrolide antibiotic

Common Injectable Dosage Forms:

Powder for Injection: 500 mg in 10 mL vials

Dosage Ranges:

The usual dose for community-acquired pneumonia is 500 mg IV as a single daily dose for 2 or more days followed by oral therapy of 500 mg/day for a total of 7-10 days.

The usual dose for treatment of pelvic inflammatory disease caused by Neisseria gonorrhoeae, Chlamydia trachomatis, or Mycoplasma hominis is 500 mg IV for 1-2 days followed by oral therapy of 250 mg/day for a total of 7 days.

Administration and Stability: Injections should be administered IV over a short period of at least 60 minutes. Do not inject by IM route or as bolus IV. Reconstituted solution is stable for 24 hours at room temperature or 7 days when stored under refrigeration. Mix with compatible diluents to a final concentration of 1 mg/mL or 2 mg/mL. Compatible diluents include Normal Saline (NS), ½ NS, Lactated Ringer’s Solution, 5% Dextrose, 5% Dextrose in ½ NS, 5% Dextrose in 1/3 NS, 5% Dextrose in ½ NS with 20 mEq KCl, 5% Dextrose in Lactated Ringer’s Solution. pH: 6.4-66

Pharmacology/Pharmacokinetics: Azithromycin binds to the 50S ribosomal subunit of susceptible bacteria thereby suppressing protein synthesis. Distribution occurs to most body tissues except CSF and aqueous humor of the eye. Excretion occurs primarily through the bile as unchanged drug. The long half-life is 68 hours may be due to extensive tissue uptake and slow release of drug from tissues.

Drug and Lab Interactions: Use with caution in patients on cyclosporine. May increase risk of severe myopathy or rhabdomyolysis in patients taking HMG-CoA reductase inhibitors. May cause QT prolongation when coadministered with amiodarone.

Contraindications/Precautions: Contraindicated in patients with a history of hypersensitivity to macrolides. Use caution in patients with impaired hepatic function. Use with caution in those with QT prolongation. Pseudomembranous colitis and secondary bacterial infections may occur with broad-spectrum antibiotics; contact physician if diarrhea becomes severe or persistent. Do not use for complicated pneumonia, gonorrhea, or syphilis. Pregnancy Category B.

Monitoring Parameters: LFTs

Adverse Effects: The most common adverse effects include DIARRHEA (4.3%), nausea (3.9%), vomiting (1.4%), and abdominal pain (2.7%). Intravenous therapy may cause pain at the injection site (6.5%) and local inflammation (3.1%). Rare cases of angioedema and anaphylaxis have occurred.

In this article, we will discuss about Macrolide. So, let’s gets started.

Definition

Macrolide is a class of antibiotic which are effective against Gram-positive bacteria (excluding enterococci) and limited Gram-negative bacteria, it is also effective against Mycoplasma pneumoniae, Treponema pallidum, Campylobacter spp., Bordella pertusis, Chlamydia trachomatis, Legionella spp., Borella spp.,…