PT Master Guide

Efficacy and Safety Analysis of IL-17A/IL-17F Dual Inhibitors (e.g., Sonelokimab) in Psoriatic Arthritis and Spondyloarthritis Researchers developed sonelokimab as a nanobody. It blocks both IL-17A and IL-17F. These cytokines drive inflammation in psoriatic arthritis (PsA) and spondyloarthritis (SpA). Dual inhibition offers stronger control than blocking IL-17A alone. Efficacy in Psoriatic…

Mixed Connective Tissue Disease (MCTD) Mixed Connective Tissue Disease (MCTD) is a rare autoimmune disorder. It combines features of several connective tissue diseases. Doctors often describe it as an overlap syndrome because it shows symptoms of Systemic Lupus Erythematosus (SLE), Systemic Sclerosis (Scleroderma), and Polymyositis. Key Features of MCTD MCTD is strongly associated with high…

Juvenile Idiopathic Arthritis: Long-term Outcomes and Growth Effects Doctors define Juvenile Idiopathic Arthritis (JIA) as a chronic autoimmune condition. It affects children under 16 years of age. Moreover, it causes joint inflammation, pain, and stiffness that can last for months or years. Researchers actively study the long-term effects of JIA. They focus on how the disease impacts physical…

Psoriatic Arthritis vs Rheumatoid Arthritis: A Comparative Analysis Psoriatic Arthritis (PsA) and Rheumatoid Arthritis (RA) are two common inflammatory joint diseases. They share some similarities but differ significantly in many aspects. Doctors must understand these differences for accurate diagnosis and effective treatment. Clinical Features Rheumatoid Arthritis usually affects joints…

AI/ML for Patient Stratification and Treatment Response Prediction in Rheumatology Researchers actively use AI and machine learning to stratify patients in rheumatology. These tools combine electronic health records (EHR), medical imaging, and transcriptomics data. First, they integrate different data types into a single model. This approach helps doctors predict treatment responses more…

Kawasaki Disease vs. Multisystem Inflammatory Syndrome in Children (MIS-C): Comparative Analysis Doctors often compare Kawasaki Disease and MIS-C because both conditions affect children. Moreover, they share several similar symptoms. However, important differences exist between them. What is Kawasaki Disease? Kawasaki Disease is a rare inflammatory condition. It mainly affects children under five…

Role of Inflammasomes and Cytokines in Rheumatic Disease Progression Inflammasomes and cytokines play central roles in rheumatic diseases. These powerful biological components drive inflammation and tissue damage over time. Researchers continue to study them to develop better treatments. What Are Inflammasomes? Inflammasomes act as sensors inside immune cells. They detect danger signals from…

Macrophage Activation Syndrome in Systemic Juvenile Idiopathic Arthritis: Biomarker Discovery and Predictive Scoring System Researchers actively investigate Macrophage Activation Syndrome (MAS) in systemic Juvenile Idiopathic Arthritis (sJIA). This life-threatening complication develops suddenly and requires early detection. As a result, timely intervention can significantly improve patient…

IgG4-Related Disease: Diagnostic Criteria Validation in Indian Cohort IgG4-related disease is a rare immune disorder. It causes inflammation and swelling in multiple organs. Doctors often find it difficult to diagnose because symptoms vary widely. Researchers recently conducted a study to validate diagnostic criteria in Indian patients. They focused on the ACR/EULAR classification criteria. These…

Hepatocellular Carcinoma in Patients with NAFLD – Emerging Risk Factors Non-alcoholic fatty liver disease (NAFLD) now drives many cases of hepatocellular carcinoma (HCC). Doctors observe a steady rise in HCC among NAFLD patients worldwide. Moreover, this trend appears even without cirrhosis in many cases. Furthermore, obesity plays a major role in this link. Excess body fat leads to chronic…

Early Detection of Cardiotoxicity from Targeted Cancer Therapies Doctors now pay close attention to heart damage caused by targeted cancer therapies. Drugs such as HER2 inhibitors (trastuzumab) and tyrosine kinase inhibitors (TKIs) can harm the heart. Moreover, early detection helps protect patients while they continue cancer treatment. Understanding Cardiotoxicity Targeted therapies attack…

Proton Therapy vs Conventional Radiotherapy in Head and Neck Cancers Head and neck cancers pose a major health challenge in India. Doctors often use radiotherapy as a key treatment. Conventional radiotherapy, such as Intensity-Modulated Radiation Therapy (IMRT), delivers radiation using X-rays. However, it also affects nearby healthy tissues. Proton therapy offers a more precise alternative. It…

Traditional Indian Diets Help Prevent Lifestyle Diseases Traditional Indian diets play a powerful role in preventing lifestyle diseases. These diets use natural ingredients and balanced cooking methods. Moreover, they focus on whole foods that support long-term health. Key Components of Traditional Diets Indian meals include plenty of whole grains, pulses, fresh vegetables, and fruits. People use…