#lysosomal

This study reveals how KICSTOR and GATOR1 assemble into a crescent-shaped lysosomal complex that regulates mTORC1 during amino acid starvation and how SAMTOR binds KICSTOR in an S-adenosylmethionine-incompatible conformation to couple methionine sensing to mTORC1 regulation. Read more about this post… Credits: Source Disclaimer

Macrophages rely on lysosomes to balance microbial killing with self-protection, generating reactive oxygen and nitrogen species during phagocytosis. Using platinum nanoelectrodes, researchers at Wuhan University tracked these reactive molecules in real time, revealing that lysosomal pH acts as a chemical dial. Acidic conditions favor hydrogen peroxide, while mild alkalinization promotes nitric…

Science, Volume 389, Issue 6762, August 2025. Summary Without specific content details from the hypothetical August 2025 issue of Science, a summary is impossible. However, assuming a typical issue, a generic 100-word summary would highlight the breadth of scientific topics covered. It likely features cutting-edge research across disciplines like biology, physics, chemistry, and environmental…

Artificial intelligence is becoming progressively significant in drug discovery. Advances in the use of Big Data, learning algorithms and strong PCs have now empowered specialists at the College of Zurich (UZH) to more readily grasp a serious metabolic sickness.

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