A poultice made from elderberry leaves, prickly pear cactus, and creeping mallow would be made to be placed upon an inflamed area.

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For severe headaches, five cocklebur leaves would be coated with salt and vinegar and placed on the head.

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Identified this one out in the swamp yesterday. It seems like there has been a pretty solid use of it in Native American communities medicinally. Several of the sources do mention a build up of toxicity, so it’s not recommended as a food. Used mainly as root poultices. Aerial parts can be used as a more gentle medicinal healing washes. The video below also talks about uses in spiritual healing and regeneration. I gathered the aerial parts of two plants and plan on going back to experiment with the roots. I found at least three huge patches. Photos are my own.

“In herbalism, an herbal wash is a concentrated plant infusion or decoction applied topically rather than taken internally. When prescribed for a "general illness," it is usually used to soothe the skin, reduce fevers, or relieve muscular and joint pain through transdermal absorption.”

While the excerpt above mentions using it internally for stomach upsets information at this this link states that it is toxic, especially when consumed in large quantities:

Couldn’t find a lot of concrete information but there are documented sources of the plant being used by a multitude of Native American tribes:

Lizard's tail is a medicinal and decorative plant native to eastern North America. The common name and the genus name, from the Greek sauros (lizard) and oura (tail), describe the shape of the drooping flower bunch.

Look for Lizard's Tail in lightly shaded areas along the edges of ponds and in marshes. In summer, clusters of tiny, fragrant, white flowers line slender stalks with drooping tips.

Lizard's Tail has many traditional herbal uses as an anti-inflammatory, poultice, stomachic and sedative.

https://www.pwconserve.org/plants/lizardstail.html