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Managing Primary Biliary Cholangitis Liver Disease https://dearkish.blogspot.com/2025/10/managing-primary-biliary-cholangitis-liver-disease.html Treatment for Primary biliary cholangitis must be multidisciplinary because it frequently coexists with other autoimmune disorders.
Managing Primary Biliary Cholangitis Liver Disease
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Ductopenia
vanishing bile duct syndrome (loss of intrahepatic bile ducts)
Causes: PBC (MCC in adults), failing liver transplantation, HD, GVHD, sarcoid, CMV, HIV, medication toxicity
Acetaminophen tox: centrilobular or diffuse necrosis
Alcoholic hep: hepatocyte swelling and necrosis, Mallory bodies, neutrophilic infiltration
PSC: periductal portal tract fibrosis and segmental stenosis of extrahepatic and intrahepatic ble ducts
TPN (for 2-3wk) --> cholestasis --> fibrosis
Hep B hepatocellular injury, sinusoidal cell reactive changes, inflammation, fibrosis of the portal tracts
