#interferon

SLIRP: an anomalous factotum on nuclear signaling SLIRP (SRA stem-loop interacting RNA binding protein) was firstly identified in 2006 and found to bind to a functional substructure of SRA called STR7. Steroid receptor RNA activator (SRA), the only known RNA coactivator, augments transactivation by nuclear receptors (NURs). SLIRP is expressed in normal and tumor tissues, contains an RNA…

Spontaneous, persistent, T cell–dependent IFN-γ release in patients who progress to Long Covid

Abstract

This analysis made it clear that the difference between those who were improving and those who were not was in the immune system’s interferon-led response to the virus. Interferons are proteins that act like the body’s alarm system against viruses and other harmful invaders. When a virus infects a cell, the cell sends out interferons to warn nearby cells. These nearby cells then prepare to defend themselves, making it harder for the virus to spread. All of these responses produce specific biological signatures that have been determined in various experiments and exist in databases.

Our first line of defense vs #SARSCoV2 are interferons, our innate immunity, a complex system not yet exploited for prevention and therapy. A great new review/perspective here @ImmunityCP | via Eric Topol @EricTopol

Slow and Steady

Just like the quiet, continuous backing of friends and family is the most empowering form of support, sometimes steady treatment is more effective than large single bursts of medicine. Colorectal cancers are particularly deadly when they spread to other parts of the body, which can happen even in patients who have the initial tumour surgically removed. Experiments have tried to reduce this spread by boosting the immune system with interferon alpha – a small protein that helps coordinate the immune system – but found limited success because of the side-effects of a heavy dose. A new study instead supplied a small steady stream of interferon alpha to mice with implanted tumours. Spread to the liver (pictured, cancer cells in green) was reduced as the immune system was better equipped to fend off intruders, and there were minimal side-effects. This approach might ultimately increase the efficacy of tumour removal surgery, keeping cancer away.

Written by Anthony Lewis

Image by Lorena Maria Ferreira and Giovanni Sitia, relating to work by Ngoc Lan Tran, Lorena Maria Ferreira & Blanca Alvarez-Moya et al

Division of Immunology, Transplantation and Infectious Diseases, IRCCS San Raffaele Scientific Institute, Milan, Italy

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in eLife, October 2022

Navet-Interferon (hỗ trợ khống chế bệnh do virus trên heo)

THÀNH PHẦN Interferon1.000.000 UI CÔNG DỤNG Phòng các bệnh do vi rút và hỗ trợ điều trị cùng với kháng sinh trong các bệnh do vi khuẩn ở gia súc. Giúp tăng đáp ứng miễn dịch khi sử dụng vắc xin.  CÁCH DÙNG VÀ LIỀU DÙNG Cách dùng: Pha 1 lọ với 20ml nước cất hoặc nước sinh lý vô trùng, lắc kỹ trước khi dùng. Tiêm bắp thịt, (1ml/ 10kg thể trọng/ ngày). Liều điều trị: 5.000 UI/ kg thể trọng/…

Tingkatkan imuniti badan melawan penyakit

Macam mana nak tingkatkan imuniti badan untuk lawan penyakit? Salah satu caranya, dengan NUTRIFERON SHAKLEE. Kenapa pulak Nutriferon boleh bantu tingkatkan imuniti? Haaa jom saya kongsikan infonya. . . Siapa yang perlukan Nutriferon ni? Nutriferon Meningkatkan interferon dalam badan. mereka yang selalu sakit, selesema dan demam. mereka yang mempunyai imunisasi badan yang lemah. mereka yang…