#hla-dr3

HLA: A Factor in Developing IgE to Chemical Conjugates Chemicals can conjugate with cells in the body, and the body can develop IgE to that chemical-cell conjugate. . . There was an increased frequency of HLA-DR3 in workers exposed to acid anhydride who developed IgE to acid anhydride-albumin conjugates. (Young et al.) (HLA, among other things they do, partially determine response to chemicals. An increased frequency of HLA-DR3 was found in one CFS study but not others.)

Hypersensitivities: HLA-DR3 & IgE to Chemicals "There is evidence that HLA class 2 alleles contribute to the risk of sensitization and asthma caused by low-molecular-weight chemical sensitizers. HLA-DR3 is associated with an increased risk of developing specific IgE to trimellic anhydride (TMA) and complex platinum salts such as ammonium hexachloroplate (ACP)." (Taylor et al.)