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A new array of sensors can record electrical signals directly from the surface of the human brain in record-breaking detail: 100 times higher resolution than today's clinical tools. This could improve neurosurgeons' ability to remove brain tumors safely and surgically treat drug-resistant epilepsy.
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Objective To determine whether training with a brain–computer interface (BCI) to control an image of a phantom hand, which moves based on cortical currents estimated from magnetoencephalographic signals, reduces phantom limb pain. Methods Twelve patients with chronic phantom limb pain of the upper limb due to amputation or brachial plexus root avulsion participated in a randomized single-blinded crossover trial. Patients were trained to move the virtual hand image controlled by the BCI with a real decoder, which was constructed to classify intact hand movements from motor cortical currents, by moving their phantom hands for 3 days (“real training”). Pain was evaluated using a visual analogue scale (VAS) before and after training, and at follow-up for an additional 16 days. As a control, patients engaged in the training with the same hand image controlled by randomly changing values (“random training”). The 2 trainings were randomly assigned to the patients. This trial is registered at UMIN-CTR (UMIN000013608). Results VAS at day 4 was significantly reduced from the baseline after real training (mean [SD], 45.3 [24.2]–30.9 [20.6], 1/100 mm; p = 0.009 < 0.025), but not after random training ( p = 0.047 > 0.025). Compared to VAS at day 1, VAS at days 4 and 8 was significantly reduced by 32% and 36%, respectively, after real training and was significantly lower than VAS after random training ( p < 0.01). Conclusion Three-day training to move the hand images controlled by BCI significantly reduced pain for 1 week. Classification of evidence This study provides Class III evidence that BCI reduces phantom limb pain.
事故などで失った手足がまるで存在するかのように感じて痛む「幻肢痛（げんしつう）」の患者に、実在する方の腕の映像を見せながら、その腕を動かそうとする脳信号を送るリハビリを実施したところ、短期間で痛み
A novel neural prosthesis providing long-term electrocorticography recording and cortical stimulation for epilepsy and brain-computer interface
A novel neural prosthesis providing long-term electrocorticography recording and cortical stimulation for epilepsy and brain-computer interface
J Neurosurg 130:1166–1179, 2019
Wireless technology is a novel tool for the transmission of cortical signals. Wireless electrocorticography (ECoG) aims to improve the safety and diagnostic gain of procedures requiring invasive localization of seizure foci and also to provide long-term recording of brain activity for brain-computer interfaces (BCIs). However, no wireless devices aimed at…
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A novel neural prosthesis providing long-term electrocorticography recording and cortical stimulation for epilepsy and brain-computer interface
A novel neural prosthesis providing long-term electrocorticography recording and cortical stimulation for epilepsy and brain-computer interface
J Neurosurg 130:1166–1179, 2019
Wireless technology is a novel tool for the transmission of cortical signals. Wireless electrocorticography (ECoG) aims to improve the safety and diagnostic gain of procedures requiring invasive localization of seizure foci and also to provide long-term recording of brain activity for brain-computer interfaces (BCIs). However, no wireless devices aimed at…
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A lot of information in this paper, and very interesting research.
NCI-Funded Tmist Study Compares 2-D and 3-D Mammography for Finding Breast Cancers
NCI-Funded Tmist Study Compares 2-D and 3-D Mammography for Finding Breast Cancers
The Tomosynthesis Mammographic Imaging Screening Trial (TMIST), the first randomized trial to compare two types of digital mammography for breast cancer screening, is now open for enrollment. The study was developed by the ECOG-ACRIN Cancer Research Group (ECOG-ACRIN) and the National Cancer Institute (NCI), part of the National Institutes of Health. ECOG-ACRIN is leading the trial.
TMIST researc…
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Wisconsin Cancer Patients Test Encouraging Lymphoma Treatment
Wisconsin Cancer Patients Test Encouraging Lymphoma Treatment
Half of the patients in a Wisconsin Oncology Network (WON) clinical trial for a rare blood cancer are still in remission eight years after beginning treatment, according to new results of a follow-up to the study.
The results were presented at the annual meeting of the American Society of Hematology conference in San Diego earlier in December.
Mantle celllymphoma (MCL) is a rare subtype of…
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