Probably more medical detail than opsec calls for, but there's practically zero research on nonbinary chemical gender transition β so I'm throwing my trip report into the collective 'net.
I am nearly 29, knew I was trans since 17 and I have been on HRT (estrogen) on and off for the past 18 months with testosterone for the last 6. Currently: 8mg Estradiol Enanthate weekly, plus 25mg testosterone weekly.
The hypothesis: The body auto-converts excess TβE and excess EβT, so it can handle high levels of both without much trouble. Women regularly take testosterone during menopause β this should be doable.
My theory: Take high E to block natural T production, then supplement a tiny bit of T to compensate. Should keep everything contextually balanced.
Six months in, and I just got my labs back. My doctor (not amused by this experiment) is shocked: I'm healthier than I've ever been across every metabolic marker. Dead center on every single metric. Blood pressure normal (first time ever). Weight stable. I have some breast growth starting, but no solidified nodules β so with raloxifene I could revert 90%+ if I wanted (TBD). They are very sensitive, for better or worse.
I have noticed my body becoming more feminine (appreciated), which is saying something since I am naturally broad and muscular. Think of a very masc blacksmith-NPC-character-model kind of build. I have curves now. Skin is overall softer. Body hair is much thinner (previously was bold, black, and gnarly). Face is smoother, jawline more defined, but the face itself is a bit rounder, especially in the cheeks.
Mental state is solid. Making real progress on projects, feeling hopeful, taking more risks and actually being comfortable with it. More open, more outgoing. Before this was quite depressed, anxious, paranoid, unable to make decisions, and just felt worthless, now its the exact opposite - I have tried every anti-depressant around, and had great luck with LSD, but this has been by far the most 'calm', happy, and level-headed I have ever been. That said, on pure estrogen, my mental clarity is certainly sharper. The combo is still clear enough though.
I understand why most queer people hate these kinds of reports (archived) and this kind of experimentation, trust me my friends make that very clear. And sure, I'm probably still denying plenty of things to myself. But , from a research perspective, this has always fascinated me, and the literature is so thin that I might as well add a small, informal case study to the mix.
