#dendritic cells

Department of Molecular Biosciences, The University of Texas at Austin, Austin, TX, USA Jayashree Srinivasan, Colin R. Moore, Aparna Calindi, John F. Moore, Hilary J. Selden & Lauren I. R. Ehrlich Department of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA Bryan R. Helm & Qi Liu Department of Cell and Developmental Biology, Vanderbilt University School of Medicine,…

Ashby, K. M. & Hogquist, K. A. A guide to thymic selection of T cells. Nat. Rev. Immunol. 24, 103–117 (2024). Article  PubMed  Google Scholar  Klein, L. & Petrozziello, E. Antigen presentation for central tolerance induction. Nat. Rev. Immunol. 25, 57–72 (2025). Article  PubMed  Google Scholar  Ohnmacht, C. et al. Constitutive ablation of dendritic cells breaks self-tolerance of CD4 T cells…

Nature Immunology, Published online: 29 August 2025; doi:10.1038/s41590-025-02272-x LPS structure shapes Treg cells Summary A 2025 Nature Immunology study reveals that the structure of lipopolysaccharide (LPS), a major component of gram-negative bacteria, significantly influences the development and function of regulatory T cells (Treg cells). These Treg cells are crucial for immune tolerance…

Metabotropic glutamate receptor 4-mediated glutamatfergic signaling reshapes the tumor microenvironment by regulating dendritic cell maturation Summary Metabotropic glutamate receptor 4 (mGluR4) signaling in dendritic cells (DCs) significantly alters the tumor microenvironment. Activation of mGluR4, a glutamate receptor, modulates DC maturation, impacting their ability to stimulate T cells and…

Antigen Presenting Cells Antigen-presenting cells (APCs) play a crucial role in the immune system, bridging innate and adaptive immunity. They are responsible for capturing, processing, and presenting antigens to T cells, thus enabling the body to recognize and respond to pathogens, cancerous cells, and other foreign substances. The primary professional APCs are dendritic cells, macrophages, and…

Propaganda!

The Golgi apparatus, also known as the Golgi complex, Golgi body, or simply the Golgi, is an organelle found in most eukaryotic cells. Part of the endomembrane system in the cytoplasm, it packages proteins into membrane-bound vesicles inside the cell before the vesicles are sent to their destination. It resides at the intersection of the secretory, lysosomal, and endocytic pathways. It is of particular importance in processing proteins for secretion, containing a set of glycosylation enzymes that attach various sugar monomers to proteins as the proteins move through the apparatus.

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