Scientific Names: Urtica dioica, Urtica urens
Other Common Names: Common nettle, greater nettle, nettles
Overall Safety: 😐
Therapeutic Efficacy and Considerations:
Osteoarthritis: 🙁 Preliminary studies suggest the topical use of whole leaf for arthritis may have some benefit, but current evidence is not strong enough to support use. In addition, the adverse event profile and difficulties in properly handling, obtaining, and preparing the leaves, mean that the risks outweigh possible benefits at this time. Use is not recommended. General dosing is topical application of whole leaves to painful areas daily as needed.
Benign Prostatic Hyperplasia: 😐 Although several controlled studies exist, evidence available in English is limited to two case studies that demonstrated positive improvements in symptoms, but no effect on prostate volume. Although more studies are warranted, use for this indication cannot be recommended at this time. Stinging nettle is often used in combination products for BPH along with herbs with firm evidence for efficacy; as stinging nettle is generally well tolerated, especially in low doses, use of these products does not have to be discouraged. Usually given as 600-1200 mg of a 5:1 root extract daily OR 4-6 g root daily as a tea.
Allergic Rhinitis: 🙁 Current evidence does not support use for this indication. Normal dose is 300 mg extract (above ground parts) three times a day. Up to 300 mg seven times daily has been used.
Root: Extracts competitively inhibit the binding capacity of sex hormone binding globulin and inhibit aromatase and 5-α-reductase. Inflammation mediators are affected and weak anti-inflammatory activity may be present.
Leaves: Leaves contain beta-sitosterol and multiple flavonoids such as quercetin, is thought to be a mast-cell stabilizer and have anti-inflammatory properties. The nettle leaf hairs contain histamine, serotonin, and acetylcholine, and all which may cause local irritation, although the leaves seem to have local anesthetic properties. Leaves contain high amounts of vitamin C, carotene, vitamin K, potassium, and calcium, and have some diuretic activity.
Drug Interactions:
The leaves may interact with WARFARIN (due to vitamin K content), hypoglycemic agents, antihypertensives, and CNS depressants with above ground parts. Root: 5-α-reductase inhibitors or hormonal therapies.
Contraindications/Precautions:
The root is contraindicated during pregnancy due to 5-alpha reductase inhibition. The leaves should be used with great caution or not at all during pregnancy and lactation. Topical preparations may cause allergic reactions.
Adverse Effects:
May cause diarrhea, GI complaints, and edema. Local irritation with topical application. Note: To use whole leaves topically, the underside (non-stinging side) is scored and then applied to the skin. Gloves should be worn while preparing leaves as contact with the stinging side can cause irritation up to 12 hours.