Jul 2
Programming Mn(II) coordination in self-assembling peptides amplifies mtDNA-driven STING signaling for potent antitumor immunity - Research
Activation of the cGAS-STING pathway is a powerful antitumor strategy, but its therapeutic performance is often constrained by insufficient cytosolic DNA cues. Here, we report a bioinspired metallopeptide nanoassembly, RKLAHE-Mn, formed through dynamic N,O-bidentate coordination between Mn(II) and a programmable hexapeptide scaffold. By leveraging specific interactions between histidine and…
#amplifies#antitumor#Chenyang Wang#Coordination#doi:10.1016/j.mtbio.2026.103373#Guoyu Xia#immunity#MEDLINE#MnII#mtDNAdriven#National Center for Biotechnology Information#National Institutes of Health#National Library of Medicine#NCBI#NIH#NLM#Peptides#PMC13315962#pmid:42382717#Potent#programming#PubMed Abstract#research#selfassembling#Signaling#STING#Zhen Zheng
