Outfoxing Chickenpox
Like one rotten egg can drag a whole group of impressionable friends into trouble, cells infected with varicella zoster virus – the virus that causes chickenpox and shingles – corrupt those around them. A hallmark of the virus’ impact in infected regions is an amalgamation of cells, all fused together to form a growing mass with many nuclei (usually the single command centre of any individual cell). Shingles can have lasting and harmful effects, and comprehensive vaccines and treatments are still being improved, so developing our understanding of the molecular basis of the virus is essential. A new study showed that inhibiting an enzyme called calcineurin increased cell fusion (pictured post treatment, with infected cells in red and nuclei in blue), but suppressed the spreading of the virus. Identifying this pathway of cell fusion regulation provides a new perspective for potential antiviral strategies to put chickenpox back in its box.
Written by Anthony Lewis
Image from work by Momei Zhou and colleagues
Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA
Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)
Published in PLOS Pathogens, November 2020
You can also follow BPoD on Instagram, Twitter and Facebook
