#bone fracture

Fractured Relationships

Break a bone and a frenzy of activity ensues to repair it. Bone-forming cells (osteoblasts) and their precursors (osteoprogenitors) take charge. However, fractures don’t always heal well. Consequently, growth factors are sometimes given to promote healing, specifically BMP which promotes bone formation and PDGF-BB which maintains osteoprogenitor numbers. Researchers investigate how they work in a mouse bone fracture model. MicroCT of fractured bones (pictured) revealed that adding high dose BMP, low dose BMP or PDGF-BB (top, left to right) promoted bone regeneration compared with no treatment (bottom left) or combining different BMP doses with PDGF-BB (bottom middle and right). Analysing the cell types revealed that BMP2 alone increased osteoblast and osteoprogenitor numbers but failed to do so when combined with PDGF-BB. While separately BMP2 and PDGF-BB promote bone healing, together they have the opposite effect. Further unpicking their interactions may help advance bone healing treatments.

Written by Lux Fatimathas

Image adapted from work by Sanja Novak and colleagues

Center for Regenerative Medicine and Skeletal Development, UConn Health, Farmington, CT, USA

Image originally published with a Creative Commons Attribution 4.0 International (CC BY 4.0)

Published in npj Regenerative Medicine, January 2023

That depends on how angry Izuku was at the time, aka how clean the break was.

The whole point about breaking Bakugou's wrist is that it would have weakened them, which is not a good thing when you create explosions with your palms. It would put strain on his wrists and hurt him every time he uses his quirk.