Life for the Lone Wanderer is so brutal and lonely. None of the companions can really become your friend or are interested in being such. Two of them are slaves and one is a robot you own. None of them show much genuine positive feeling towards you except maybe Butch, and he bullied you violently throughout your entire childhood. Even your Mr. Handy robot (should you get the house in Megaton) is constantly making comments on how annoyed it is with you under its breath, which it can’t really do cause it’s a robot so the insults are definitely audible. Your only family left you and will eventually die in front of you for a cause he deems more important than you.
Even people who are nice to you want something from you and will try to extort you for it. Even the good people like Three Dog or Victoria Watts or the kind people like Moira or the people of Oasis constantly asking you for things, dangerous things, difficult decisions, you can never really catch a break. You’re trying to people please and help and feel some sort of, any sort of, connection to anyone because you are so, so lonely, all while dealing with this horrible new world you’ve been unwillingly and traumatically thrust into plus the loss of everything and one you’ve ever known.
Even Amata rejects you in the end. I can’t imagine the absolute devastation of knowing that you will never be allowed back home and that you have lost everything, every friend, every relationship, and no one is interested in fostering new ones. 
There’s just nothing to cling onto for support, and did I mention throughout it all you are a 19 year old baby? Rough stuff
