#bleedingdisorders

💉 Awareness saves lives! On World Hemophilia Day, Nordic Formulations is dedicated to raising awareness about bleeding disorders and supporting better diagnosis & care. ❤️

Thousands remain undiagnosed — it’s time to educate, support, and act. Every life matters, every drop counts.

Together, let’s build a future where no one suffers in silence.

The global hemostasis diagnostics market size is expected to reach USD 1.49 billion by 2030, registering a CAGR of 4.5% from 2025 to 2030, according to a new report by Grand View Research, Inc. The market is likely to show significant growth due to various factors, such as the growing geriatric population across the globe, advancements in diagnostic technologies, increasing awareness of bleeding and clotting disorders, and the rising prevalence of chronic diseases.

One of the primary drivers of the market is the growing geriatric population. As people age, the likelihood of developing conditions that affect hemostasis, such as venous thromboembolism, atrial fibrillation, and other cardiovascular diseases, increases. Older individuals are also more likely to undergo surgeries that require accurate monitoring of coagulation levels to avoid complications like excessive bleeding or clot formation. This demographic trend is boosting the demand for diagnostic tools that can assess blood clotting and bleeding risks.

Technological advancements in terms of product development are also contributing to market growth. The development of sophisticated and accurate diagnostic analyzers, such as point-of-care devices, has made it easier for healthcare providers to quickly monitor coagulation parameters across various healthcare settings. These advancements have improved the speed and efficiency of diagnosing hemostasis disorders, which is particularly important in emergency and critical care settings.

In addition, innovations in testing platforms, such as automated analyzers and molecular diagnostic tests, have expanded the range of tests available, allowing for more precise detection of underlying causes of bleeding and clotting disorders.

Increased awareness and better understanding of bleeding disorders owing to continuous research in emerging economies are driving the growth of the hemostasis diagnostics market. Public health campaigns and medical research have highlighted the importance of early diagnosis and intervention in managing conditions such as hemophilia, deep vein thrombosis (DVT), and pulmonary embolism. As a result, there is a greater emphasis on regular screening and monitoring of patients at risk of these conditions, which increases the demand for hemostasis diagnostic tests.

The rising prevalence of chronic diseases, particularly those related to the cardiovascular system, is also contributing to the growth of the market. Cardiovascular diseases often lead to clotting disorders, either due to the formation of blood clots in the arteries or the use of anticoagulant therapies to prevent strokes and heart attacks. As more individuals are diagnosed with chronic cardiovascular conditions, there is an increased need for diagnostic tests that can monitor blood clotting and bleeding risks, further driving the market.

Furthermore, the growing adoption of personalized medicine is playing a role in the hemostasis diagnostics market. In the context of hemostasis, personalized medicine can help identify patients who are at higher risk of bleeding or clotting disorders, enabling healthcare providers to choose the most appropriate diagnostic tests and treatments. This trend is encouraging the development of more targeted diagnostic tools that can cater to the specific needs of individual patients.

Some key players in the market are F. Hoffmann-La Roche AG; Danaher Corporation; Sysmex Corporation; Siemens Healthineers; Horiba Medical; Haemonetics Corporation; HemoSonics, LLC; Sterile Safequip and Chemicals LLP; TECO Medical Instruments; Stago and more. Key strategies opted by the companies include innovation in product development, such as introducing more advanced, automated, and point-of-care diagnostic devices that offer faster, more accurate results. Strategic partnerships and collaborations with hospitals, research institutions, and other healthcare providers are also crucial for expanding market reach and enhancing product offerings. Additionally, companies are focusing on expanding their product portfolios to include a broader range of diagnostic tests, catering to both routine and specialized testing needs.

For More Details or Sample Copy please visit link @: Hemostasis Diagnostics Market Report

Hemostasis Diagnostics Market Report Highlights

Based on product, consumables accounted for the largest revenue share of 61.1% in 2024. With the increasing number of tests being performed, the demand for consumables is likely to show lucrative growth over the forecast period.

Based on test, the prothrombin time test dominated the market and accounted for the largest share of 31.5% in 2024.The PT test can be performed in various healthcare settings, including hospitals, clinics, and even point-of-care locations, making it accessible for timely diagnosis and treatment. Additionally, the test has a relatively short turnaround time, allowing clinicians to make rapid decisions regarding patient care.

Based on end use, the hospitals segment dominated the market with the largest revenue share of 57.7% in 2024. The segment dominance is attributed to large patient volumes being tested in hospitals.

North America dominated the global market owing to well-established healthcare infrastructure allowing timely diagnosis and management of patients with bleeding and clotting disorders.

Hemophilia is a rare bleeding disorder that requires lifelong care and awareness. On this World Hemophilia Day 2025, let’s stand together in support of those affected and spread knowledge about the importance of early diagnosis, treatment options, and support systems. 💉🧬

👨‍⚕️ At PACE Hospitals – The Best Hospital in Hyderabad, Telangana, India, we’re committed to spreading awareness and providing advanced care for bleeding disorders. Our special initiative for World Hemophilia Day includes expert insights, treatment options, and support for patients and families. ❤️‍🩹

Importance of World Haemophilia Day

In 2000, it was estimated that 4 lakh persons, or around 1 in 10,000 live births, were affected by this disorder worldwide, and only 25% of those affected had access to adequate treatment. In 2019, however, a meta-analysis showed that the number of men with the inherited bleeding condition is far higher, at 11.25 lakh. 

Even in high-income nations, only about 15% of the global population, has access to effective treatment for haemophilia. The lack of resources for diagnosis and treatment leads to high mortality and morbidity rates in low- and middle-income countries.

This year, World Haemophilia Day celebrates its 31st anniversary with activities focused on encouraging the public to support government and policymakers for the provision of better treatment, prevention, and control of bleeds in persons suffering from bleeding disorders.

🔗 Check out our dedicated page for more info, resources, and how you can be part of the change:

👉 World Hemophilia Day 17 April 2025 | Theme, Importance & History

📢 Let’s amplify the voice for hemophilia warriors and educate more people about this condition. Together, we can make a difference. 💪

🩸 Experiencing symptoms of Hemophilia? Don’t delay!

If you notice unusual bleeding, frequent bruising, joint pain, or have a family history of bleeding disorders, it’s important to seek medical attention early.

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Hemophilia facts

Hemophilia is a rare genetic bleeding disorder that affects about 1 in 5,000 to 10,000 males worldwide. Here are some facts about hemophilia: - Hemophilia is caused by a deficiency in clotting factor proteins in the blood, which leads to prolonged bleeding. - There are two main types of hemophilia: hemophilia A, which is caused by a deficiency in clotting factor VIII, and hemophilia B, which is caused by a deficiency in clotting factor IX. - Hemophilia is typically an inherited disorder that is passed down through families, but in rare cases it can occur spontaneously. - Hemophilia mostly affects males, as the gene for the disorder is located on the X chromosome. Females can also be carriers of the gene and pass it on to their children. - The severity of hemophilia varies depending on the level of clotting factor in the blood. People with severe hemophilia may experience spontaneous bleeding, while those with mild hemophilia may only experience bleeding after injury or surgery. - Common symptoms of hemophilia include easy bruising, prolonged bleeding after injury or surgery, joint pain and swelling, and frequent nosebleeds. - Hemophilia can be diagnosed through blood tests that measure the level of clotting factor in the blood. - Treatment for hemophilia involves replacement therapy, in which missing clotting factor proteins are replaced through intravenous infusions. This can help prevent and control bleeding episodes. - With proper treatment, people with hemophilia can lead relatively normal lives, but they must take precautions to avoid injury and bleeding. - Hemophilia is a lifelong condition that requires ongoing medical care and management.

What is the difference between hemophilia A and B and C?

Hemophilia A, B, and C are all bleeding disorders caused by deficiencies in clotting factor proteins in the blood, but they are caused by different factors and affect people differently. Hemophilia A is caused by a deficiency in clotting factor VIII, while hemophilia B is caused by a deficiency in clotting factor IX. These two types of hemophilia are the most common, and they are both inherited in an X-linked recessive pattern, meaning the gene that causes the disorder is located on the X chromosome. As a result, hemophilia A and B mostly affect males, while females are typically carriers of the gene. Hemophilia C, on the other hand, is caused by a deficiency in clotting factor XI, which is inherited in an autosomal recessive pattern. This means that both parents must pass on the faulty gene for their child to develop hemophilia C, and it can affect males and females equally. Hemophilia C is much less common than hemophilia A and B. The severity of hemophilia varies depending on the level of clotting factor in the blood, but generally speaking, hemophilia A and B tend to be more severe than hemophilia C. People with hemophilia A or B may experience spontaneous bleeding, while those with hemophilia C may only experience bleeding after injury or surgery. Treatment for hemophilia A, B, and C all involve replacement therapy, in which missing clotting factor proteins are replaced through intravenous infusions. However, the specific treatment and dosage may vary depending on the type and severity of the disorder.

What causes hemophilia A?

Hemophilia A is caused by a deficiency or absence of clotting factor VIII in the blood, which is necessary for normal blood clotting. This deficiency is typically the result of a genetic mutation that affects the production of clotting factor VIII. The gene that controls the production of clotting factor VIII is located on the X chromosome, one of the sex chromosomes. Hemophilia A is inherited in an X-linked recessive pattern, which means that the gene mutation is located on the X chromosome. Males have only one X chromosome, so if they inherit the faulty gene from their mother, they will develop hemophilia A. Females have two X chromosomes, so they can be carriers of the gene without developing the disorder themselves. However, if a female carrier has a son, he has a 50% chance of inheriting the faulty gene and developing hemophilia A. In rare cases, hemophilia A can also occur as a result of a spontaneous genetic mutation that is not inherited from either parent. This is known as a de novo mutation. It's worth noting that hemophilia A is a rare disorder, affecting about 1 in 5,000 to 10,000 males worldwide.

What are the symptoms of hemophilia A and B?

The symptoms of hemophilia A and B can vary depending on the severity of the deficiency in clotting factor VIII or IX, respectively. Generally, the lower the level of clotting factor in the blood, the more severe the symptoms are likely to be. Here are some common symptoms: - Prolonged bleeding: This is the most common symptom of hemophilia A and B. People with hemophilia may experience prolonged bleeding after an injury, surgery, or dental work, or they may experience spontaneous bleeding without an apparent cause. The bleeding may be internal or external and can occur in any part of the body. - Bruising: People with hemophilia A and B may experience large or deep bruises that take longer than normal to heal. - Joint pain and swelling: Bleeding into the joints can cause pain, swelling, stiffness, and limited mobility. This is a common symptom in people with severe hemophilia. - Nosebleeds: People with hemophilia A and B may experience frequent or prolonged nosebleeds. - Blood in urine or stool: Bleeding can occur in the urinary or digestive tract, resulting in blood in the urine or stool. - Intracranial bleeding: In severe cases, bleeding can occur in the brain, which can cause headaches, vomiting, seizures, and other neurological symptoms. It's worth noting that the severity of hemophilia can vary, even within the same family. Some people with hemophilia may experience only mild symptoms, while others may experience severe and life-threatening bleeding episodes. Regular medical check-ups and treatment can help manage the symptoms of hemophilia and prevent complications.

How is hemophilia A and B diagnosed?

Hemophilia A and B are typically diagnosed through a combination of physical exams, medical history, blood tests, and genetic testing. - Physical exam: A doctor may examine a person with suspected hemophilia for signs of bleeding, such as bruises, joint swelling, and deformities. - Medical history: A doctor may ask about a person's personal and family medical history to determine if there is a history of bleeding disorders or if there are any risk factors for hemophilia. - Blood tests: Blood tests can be used to measure the levels of clotting factor VIII or IX in the blood. These tests can help diagnose hemophilia A or B and determine the severity of the deficiency. - Genetic testing: Genetic testing can be used to confirm a diagnosis of hemophilia A or B and identify the specific genetic mutation responsible for the disorder. This can be helpful for family planning and genetic counseling. - Bleeding time tests: In addition to clotting factor tests, bleeding time tests may be performed to assess a person's blood clotting ability. It's important to note that hemophilia is a rare disorder, so it may not be the first condition a doctor considers when evaluating someone with bleeding symptoms. A hematologist, a doctor who specializes in blood disorders, may be consulted to help make a diagnosis.

Is it possible to know if you are a carrier of hemophilia?

Yes, it is possible to know if you are a carrier of hemophilia through genetic testing. Hemophilia is an X-linked genetic disorder, which means that the gene responsible for producing the clotting factor VIII or IX is located on the X chromosome. Females have two X chromosomes, so they can be carriers of the gene mutation without developing hemophilia themselves. Genetic testing can determine if a female carries the gene mutation that causes hemophilia. This can be helpful for family planning and genetic counseling. Genetic testing can also be done for males with hemophilia to determine the specific genetic mutation responsible for their disorder. If you have a family history of hemophilia, you may want to consider genetic testing to determine if you are a carrier. A genetic counselor can help you understand the risks and benefits of genetic testing and help you make an informed decision.

What are treatments for hemophilia?

The main treatment for hemophilia A and B is replacement therapy, which involves infusing clotting factor VIII or IX into the bloodstream to replace the missing or deficient clotting factor. The clotting factor can be obtained from donated human plasma or produced synthetically in a laboratory. Replacement therapy is typically given as a preventive measure, known as prophylaxis, to reduce the risk of bleeding episodes. The frequency and dosage of replacement therapy can vary depending on the severity of the hemophilia and the individual's needs. Other treatments for hemophilia may include: - Desmopressin (DDAVP): This medication can stimulate the release of stored clotting factor VIII in mild or moderate cases of hemophilia A. - Clot-stabilizing medications: These medications can help stabilize clots and reduce bleeding in certain situations. - Gene therapy: This experimental treatment involves introducing a functional copy of the gene responsible for producing clotting factor VIII or IX into the body to help restore normal clotting function. - Physical therapy: This can help improve joint mobility and prevent joint damage caused by bleeding into the joints. - Psychological counseling: Hemophilia can have a significant impact on a person's emotional and social well-being. Psychological counseling can help individuals and families cope with the challenges of living with hemophilia. It's important for individuals with hemophilia to work closely with a healthcare team, including a hematologist, to develop a comprehensive treatment plan that addresses their individual needs and goals.

Inhibitors

Inhibitors are a potential complication of treatment for hemophilia A and B. Inhibitors are antibodies produced by the immune system that neutralize or destroy the infused clotting factor VIII or IX, rendering replacement therapy ineffective. Inhibitors occur in about 25-30% of people with severe hemophilia A and in a smaller percentage of people with severe hemophilia B. Inhibitors can also occur in people with mild or moderate hemophilia who have been treated with replacement therapy. The development of inhibitors can make it more difficult to manage bleeding episodes and may require alternative treatment strategies, such as immune tolerance induction (ITI) therapy or bypassing agents. ITI therapy involves giving frequent and high doses of clotting factor to try to overcome the immune system's response to the infused factor. This can take several months or even years to be effective. Bypassing agents, such as activated prothrombin complex concentrate (aPCC) or recombinant activated factor VII (rFVIIa), can be used to treat bleeding episodes in people with inhibitors. These agents work by bypassing the missing clotting factor and activating other proteins in the blood clotting cascade to form a clot. Inhibitors can have a significant impact on a person's treatment and quality of life. Regular monitoring of clotting factor levels and the development of inhibitors is important for managing hemophilia and preventing complications.

Infections

Infections can be a potential complication for people with hemophilia, particularly if they receive clotting factor concentrates obtained from human blood. Prior to the implementation of stringent screening and purification processes, clotting factor concentrates were a source of viral infections such as HIV and hepatitis C. Today, clotting factor concentrates are extensively screened and treated to minimize the risk of infection. However, infections can still occur, particularly if the concentrates are not stored or administered properly. Infections can also occur as a result of frequent injections or infusions, particularly in people with implanted ports or central lines. These devices can become infected and may need to be removed and replaced. Common infections in people with hemophilia include: - Hepatitis B and C: These viral infections can cause liver damage and can be spread through contaminated blood products. - HIV: This viral infection can weaken the immune system and can be spread through contaminated blood products. - Bacterial infections: These can occur at the injection or infusion site or in other parts of the body. - Fungal infections: These can occur in people with weakened immune systems or as a result of prolonged antibiotic treatment. It's important for people with hemophilia to practice good hygiene, such as washing hands regularly and cleaning injection or infusion sites properly, to reduce the risk of infection. Any signs of infection, such as fever, redness, or swelling at the injection site, should be reported to a healthcare provider immediately. Regular monitoring of liver function and viral infections is also important for people with hemophilia.

Can hemophilia be prevented?

Hemophilia is a genetic disorder, and currently, there is no known way to prevent it from occurring in individuals with a family history of the disorder. However, genetic counseling and testing can help families understand the risk of passing the disorder to their children. Prenatal testing can also be performed to diagnose hemophilia before birth. This allows parents to make informed decisions about the pregnancy and prepare for the care of a child with hemophilia if necessary. In terms of prevention of complications related to hemophilia, prophylactic replacement therapy with clotting factor concentrates can help prevent bleeding episodes and joint damage. This approach involves administering clotting factor concentrates on a regular basis to maintain a sufficient level of clotting factor in the blood. Additionally, people with hemophilia can take steps to prevent injuries and avoid activities that may increase their risk of bleeding, such as contact sports. Wearing protective gear, such as helmets and pads, can also help prevent injuries and reduce the severity of bleeding if an injury does occur. Overall, while hemophilia cannot be prevented, early diagnosis, appropriate treatment, and careful management can help individuals with hemophilia live healthy and productive lives.

What is the outlook (prognosis) for hemophilia?

The outlook for people with hemophilia has improved significantly over the past few decades due to advances in treatment and management strategies. With appropriate care, people with hemophilia can live relatively normal and healthy lives. Prophylactic treatment with clotting factor concentrates has been shown to prevent joint damage and improve quality of life in people with hemophilia. In addition, the development of new therapies, such as gene therapy, holds promise for the future treatment of hemophilia. However, the severity of the disorder can vary widely, and the outlook depends on the individual's specific situation. People with severe hemophilia are at higher risk for bleeding episodes and complications, such as joint damage, infections, and inhibitors. Regular monitoring of clotting factor levels, joint health, and potential complications is important for managing hemophilia and improving outcomes. Engaging in appropriate exercise and physical therapy can also help maintain joint health and mobility. Overall, with appropriate care and management, people with hemophilia can lead healthy and fulfilling lives. However, ongoing research and development of new therapies will continue to improve outcomes and quality of life for people with hemophilia.

What are possible future treatments for hemophilia?

Hemophilia is usually an inherited bleeding disorder in which the blood does not clot properly. This can lead to spontaneous bleeding as well as bleeding following injuries or surgery. Blood contains many proteins called clotting factors that can help to stop bleeding.