Scientists Rewrite the Genetic Code of E. Coli, and It's Drastically Different From Anything Found in Nature
Scientists Rewrite the Genetic Code of E. Coli, and It's Drastically Different From Anything Found in Nature https://share.google/yxzrbihGB8pspiNIw
The synthetic bacteria contain a shorter genetic code with 57 codons rather than 64, freeing up space for further edits that might lead to n
The synthetic bacteria contain a shorter genetic code with 57 codons rather than 64, freeing up space for further edits that might lead to new drugs or virus-resistant microbes
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That’s why scientists have been working to “free up” codons from microbes, or remove them and shorten the genetic code. They hope to one day repurpose some of these sequences so that, instead of encoding amino acids that are already accounted for, they might code for other amino acids that don’t occur naturally. This could make the microbes produce new molecules that might lead to useful drugs or materials. It might even make the microbes virus-resistant.
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“This was a gargantuan effort,” lead author Wesley Robertson, a synthetic biologist at the Medical Research Council Laboratory of Molecular Biology in England, tells New Scientist’s Michael Le Page.
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To do this, the researchers built the bacterium’s entire genome from scratch. Then, they started testing small, edited fragments of the DNA in living bacteria to determine which changes were okay to make and which ones did harm.
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“It’s a radically recoded genome,”🤏🏾😅🎯 Robertson tells Elizabeth Walsh at Chemical & Engineering News.
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Currently, Syn57 grows four times slower than normal E. coli, but the researchers expect that with further research they can accelerate its growing speed. With additional edits, it might have key uses in biotechnology and commercial applications. Since its debut in 2019, Syn61 is already being used to manufacture more reliable drugs, writes Phys.org’s Krystal Kasal.
“This work exemplifies how genome synthesis can move the genome sequences of organisms into new regions of sequence space that may not have been accessed by natural life,” 🤯 the authors write in the paper.
Meanwhile, Nyerges and his team are also getting close to their version of Syn57—they have created a 57-codon genome, but it’s broken into seven disconnected pieces of DNA, reports the New York Times. They’re now working on stitching everything together into one molecule. “We will definitely get there,” he tells the outlet.
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A lot of incredible stuff is beginning to happen 😅 and I, as well, hope that many and much of these ideas and companies make their way into a reformed and improved public markets 🤞🏾
If scientists can rewrite organic genetic evolutionary Earth code; in attempting to adapt to eternity - then Shirley public servants and citizens can rewrite inorganic public legislative Earth code in kind. Shirley🫳🏾(?)...
Place your bets
