#agenesis

Jade (2018)

New drug to regenerate teeth. Thoughts health innovators?

Kyoto University researchers have successfully used a drug to regenerate new whole teeth in mice. The novel therapeutic approach, which uses antibodies, blocks the action of a gene known to regulate the growth of excess teeth. The engineered antibody is earmarked as a new treatment for missing teeth due to a genetic disorder known as tooth agenesis. Tooth agenesis is a congenital disorder…

Agenesis, n. /ǝy-jen-uh’sis/ - Imperfect development of the body or any part of it.

Introduction: Tooth agenesis (TA) is a common developmental anomaly of the dentition with marked phenotypic and genetic heterogeneity, yet data from Middle Eastern families are limited. The aims of this study were twofold: first, to describe the clinical features and inheritance patterns of familial TA in Lebanese kindreds and to investigate rare segregating exonic variants that may contribute…

Neuroimaging shows that astrocytes are responsible for joining the 2 halves of the brain together.

A significant milestone in the evolution of the mammalian brain is the emergence of the corpus callosum, which is exclusively present in placental mammals.  This commissure forms the largest axon tract in the human brain and is required for the integration of sensory, motor, and associative processes between the two cerebral hemispheres.

In congenital absence of the corpus callosum, callosal…

Aicardi syndrome is a rare neurologic disorder first described by the French neurologist, Dr. Jean Aicardi, in 1965. It occurs almost exclusively in females (46,XX), however, it can also occur in males with Klinfelter Syndrome (47,XXY).  A handful of reports in the literature exist of Aicardi syndrome in a normal male. Some of these reports have been disputed, and it is possible that these cases…