#2439

a couple people coincidentally reblogged my rare disease day post from [last year] so. here's how that's been going. (some of this is repeat info if you click the link)

I have mast cell activation syndrome (or MCAS), an immune disorder in which my signaling cells are way too jumpy and can trigger all kinds of symptoms (up to and including anaphylaxis) in response to seemingly harmless stimuli. this is distinct from allergies as whether or not I react to a trigger can change from day to day based on how many other triggers are present, and the chemical mediators released cover a broader spectrum than just the IgE release in a classical allergic reaction. plus oftentimes symptoms are a mix of episodic and chronic, rather than being acute episodes like allergies.

triggers can be commonly understood things like certain food ingredients or scent chemicals, but can also include things like hormone fluctuations, physical or mental exertion, and the sun. I have reacted to ginger, laundry detergent, and a natural gas furnace, for example. I also do a lot worse in summer because it is both sunny and warm, and I always have to be very careful how much energy I use up or I might trigger anaphylaxis.

it's common for people with MCAS to have some level of symptoms all their life, that go unnoticed or dismissed until some precipitating event causes a substantial downturn in their condition. for me it was mono, but other infections (especially covid) and significant stressful events have also been anecdotally reported to precipitate downturns if I recall correctly, or simply being uncontrolled enough for long enough can also snowball.

diagnostic criteria for MCAS were first proposed in 2010, so the true rarity is still very up in the air. (personally I believe a lot of common wastebin diagnoses (ibd, fibro, cfs/me, etc) should be scrutinized very carefully as potential "specialty silos" of MCAS, especially given how often they tend to travel together.)

firstline treatments for MCAS include cheap medications available over the counter like loratadine, aspirin, and famotidine. my condition has become severe enough that I'm currently on third-line treatment (omalizumab injections), which does finally seem to be getting me somewhere. (this is, of course, in addition to still taking all of the first- and second-line treatments. I take 24 units of 13 medications in a given day, it's a lot to keep track of. to the point where I'm not actually sure I've counted it correctly :v then there's my monthly injections and my emergency medications on top of that.)

(those injections btw? can cost thousands of dollars even with insurance. thankfully I'm able to use the company's assistance program, so I don't pay anything out of pocket. for that one.)

EN ESPAÑOL: DOBLADA

Ginger Snaps is a 2000 Canadian supernatural horror film directed by John Fawcett and written by Karen Walton, from a story they jointly developed. The film  It was followed by a sequel, Ginger Snaps 2: Unleashed, and a prequel, Ginger Snaps Back: The Beginning, which were filmed back-to-back and both released in 2004.

The film stars Emily Perkins and Katharine Isabelle as Brigitte and Ginger Fitzgerald, two morbid teenage sisters whose relationship is tested when Ginger (who has started her period for the first time) is attacked and bitten by an unknown animal, and then later, during the next full moon, slowly starts to transform into a werewolf. The supporting cast features Kris Lemche, Jesse Moss, Danielle Hampton, John Bourgeois, Peter Keleghan, and Mimi Rogers. Wikipedia Ginger Snaps (2000) - IMDb 6'8

WATCH FILM BELOW

LINK https://ok.ru/video/1148551629426

SOURCE

SECCIÓN EN ESPAÑOL

Ginger Snaps (titulada: Feroz en México y Ginger Snaps: La poseída en Venezuela) es una película canadiense de terror del año 2000 protagonizada por Katharine Isabelle y Emily Perkins, que tuvo dos secuelas: Ginger Snaps 2: Los Malditos y Ginger Snaps: El Origen. Ginger Snaps - Wikipedia, la enciclopedia libre

VEASE LA PELICULA A CONTINUACION DOBLADA

Larva series season 3 episode 102 As time goes by

Gray is were elderly a rat old man with a long pink tail. he has the cheeks fur hair white He has a old small pink nose with mustache white and eyebrow white, two pink ears with fur hair white and a sharp teeth old man. He also has black old whiskers, the eye color, with brown eyes pink hands and pink feet.

Please let enjoy your day 😘

mulleres á beira da mar

do Cartafol de luz da mar