I'm a certified simp

Excella had known Wesker since about 2003, but had been directly close to him since about 2006, when she gained control of Tricell Inc. From 2006 to 2009, she was close to him, through which she began to experience romantic feelings that blinded her critical thinking. But even without the crush, she was indifferent to what kind of person he was, and that probably always annoyed him in people (Wesker's second report states how he hates people who elevate others only for their background and not for their personal accomplishments. Excella exalted Wesker perhaps not even for his research but for his looks, that is, she did not read between the lines at all and did not pay attention to who was actually standing in front of her).

Being indifferent to his personality, she did not notice at all, so unstable man was next to her. The object of her lust had a huge bouquet of psychological problems and inferiority complexes, which he hid behind a mask of calmness.

However, even this mask gave a crack in re5, you can tell by the animation of the sudden outburst of anger.

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But while in re5 he's angry because his plan is slowly falling apart, in the Lost in Nightmares DLC, it's much deeper than that...

He just learned the truth about his life, and his anger is probably directed at that fact. He's angry at the truth and the fact that his past continues to haunt him (Chris and Jill). His past in the form of Umbrella, who he ran away from, has also caught up with him again, turning out to be the truth he had to face. Because of his pretense and “calm” image, he never learned to deal with his emotions, and I'm surprised that Excella never noticed it, since he must have been angry when the cockroaches mutated on his ship.

Based on all of this, Excella hasn't been paying attention to the fact that the person next to her isn't what she thinks he is. Chris is blind to Wesker's psychological problems too and he is clearly not the person who would suggest he go to a psychiatrist, but he, unlike Excella, has good reasons for this. For example, he's blinded by his resentment toward Wesker (for the mansion, for kidnapping Jill, and so on), he's also blinded by hatred. But Excella treated Wesker well, was directly next to him, and still missed the fact that everything in his character screams that he needs help.

Yes, if someone had offered him psychological help, he obviously wouldn't have liked it, but he would have realized anyway that someone had shown him attentiveness. He would have felt that someone cares about something much deeper in him than his external image, and maybe that would have made a difference.

Just imagine that ONE caring person could have changed the course of further history by showing of the right attention. Especially if this person had appeared long before re5, for example in 2006, when Wesker was the most psychologically unstable because he learned the truth from Spencer. Feeling that someone didn't just sympathize with him, but wanted to help him deal with an deep problem, perhaps he would have made other decisions in the future.

After all, in fact, Wesker is not so much interested in Uroboros and power, as in getting people from it who would be equal to him and consider him. His main problem is a sense of detachment, as if he is superfluous, different from everyone else as a white crow, and so he needs a society made up of white crows like him. He strives to stop feeling "different". And for the sake of this, he has made the mistaken decision to “make others like him”, because he considers "ordinary" people unworthy.

However, he turns a blind eye to the fact that all these people he considers unworthy have a chance to merge with Uroboros and become like him. So it's the same "unworthy" people, just in a different cover, you know? This is another fact that proves that he doesn't care what kind of people will become the Uroboros users, he wants that they just exist. It's important to him that there are people like him.

And if just ONE person in his past had shown genuine empathy for his personality, advising him to see a specialist, maybe the whole RE story would have gone differently. There would be no Jill kidnapping, no Uroboros, no biological weapons and the organizations responsible for them, because Wesker, based on his words, is disgusted by war and pestilence. There would be no reason for him to do all this and pursue his dream through the dirty ways. His dream are of a world without decadence, a utopia where there is no destruction. And biological weapons are precisely the tools of war, pestilence and destruction. If he had other goals, Wesker would have gone up against BOW, and knowing how well he was able to counter his competitors, the bioterrorists wouldn't stand a chance.

Let's not forget that Wesker developed many weapons against bioweapons, the blueprints for which were later found by Blue Umbrella ("Albert System Weapon"). So even being a bioterrorist involuntarily, he developed means against BOW, indirectly speaking out against his own work