i am fucking crazy, but i am free

Avis's Disorder

An Alexandria's Genesis reimagining.

Overview:

Avis's Disorder, occasionally called 'Violet Iris Syndrome' (VIS) is an extremely rare lifelong genetic disorder that affects the eyes, hair, skin, fat tissue, and menstrual cycle. It is seen in every human population, spread through a rarely-expressed recessive gene, and most commonly observed and diagnosed within the first year of life.

Symptoms:

Avis's Disorder affects the eyes, hair, skin, and the body's fat tissue. In women, the disorder it also affects menstruation.

Eye Color

The most obvious symptom of Avis's Disorder are purple-colored irises, which range in color from blue-tinged to true purple to red-tinged. Babies born with Avis's Disorder have a non-disordered eye color at birth, which slowly turns purple over the first six months of life.

Neonatal Lipodystrophy

Those with Avis's Disorder are born extremely underweight, requiring prompt and immediate medical attention to survive, and even with medical attention, babies with Avis's Disorder have very low chances of surviving their first week of life, though these odds favorably increase with time. Low birth weight is believed to be the highest contributor to the disease's rarity.

Lipodystrophy does not usually continue into adulthood, although individuals with Avis's Disorder are at a higher risk of acquired lipodystrophy later in life, particularly after age 65.

Body Hair

Avis's Disorder usually prevents the growth of body hair, excluding hair on the scalp, eyelashes, eyebrows, and, usually in men, facial hair. The reasons behind this are unknown, although individuals with Avis's Disorder can also have Alopecia, therefore the two conditions are not believed to be intrinsically related. Contrary to popular belief, Avis's Disorder does not cause a specific hair type or color.

Skin

Avis's Disorder causes a higher production of sweat, giving the skin of those with the disorder a 'sparkling' or 'glistening' appearance. Avis's Disorder does not cause or only appear in a specific skin color, it appears in all human populations.

Menstruation

Another well-known symptom of Avis's Disorder is a 'lack of menstrual cycle', although this is a misconception. Avis's Disorder causes the body to retain all hemoglobin used in the uterine lining, giving the subsequent discharge a pale yellow-white color. Avis's Disorder also causes extremely light periods and little-to-no other menstrual symptoms, often going unnoticed by a person with the condition. Fertility is not affected by hemoglobin retention, and the implantation of a zygote causes hemoglobin to remain in the uterine lining. The reasons as to why and how Avis's Disorder causes hemoglobin retention are still unknown.

Diagnosis

Avis's Disorder is usually diagnosed during the first year of life, when the irises turn purple. Diagnosis in adulthood is rare but does happen, especially in locations without robust medical systems or proper education on the disorder, seeing as Avis's Disorder is very, very rare.

Heterochromia with a purple iris is not sufficient to fully diagnose Avis's Disorder unless other symptoms are also present, neither is having the gene sequence for the disorder, which usually does not express phenotypically.

Treatment

Avis's Disorder is a lifelong condition, but does not effect most day-to-day functioning. There is no 'cure' for the disorder.

Even so, those with Avis's Disorder are advised to avoid drugs and substances, such as cigarettes, that promote or accelerate weight loss, as doing so may lead to dangerous lypodystrophy. Pregnant people with Avis's Disorder are also advised to make regular visits to the doctor during their pregnancies, give birth in a hospital setting, and inform doctors of their condition, so infants who potentially have the disorder are given the highest chance of neonatal survival.

Neonatal lypodistrophy in infants with Avis's Disorder are treated with traditional and well-known methods used for non-Avis's Disorder infants with low birth weight.

History

Fossil evidence shows that Avis's Disorder originated in and around the same time that homo sapiens began appearing as a distinct species, likely with genes from a now-extinct retrovirus.

Once believed to be restricted to only those of European descent, genetic testing has proven that Avis's Disorder is found in every human population. Cultural evidence of Avis's Disorder is seen on each continent, with notable evidence in the tomb of King Tutankhamen, which outright records the death of a prince with purple eyes.

A common misconception is that the first recorded case of Avis's Disorder was seen in a woman named Alexandria in England during the 1300s, however there is very little evidence to support the fact that Alexandria existed at all, much less recorded in historical documentation of the disorder.

Avis's Disorder was first identified during the post-war population boom in the United States, due to advances of science and medicine allowing for better chances of low-birth weight infant survival. A pediatrician and researcher named Dr. Arthur Quinn Avis noticed that several infants suffering from extremely low birth rate later exhibited the rare trait of purple eyes, and, over the course of several decades of research, eventually collected the symptoms of Avis's Disorder into a proper diagnosis.

Research and Controversy

Dr. Avis died from pancreatic cancer in 1992, but the research he began continues to this day.

The main aspects of research into Avis's Disorder surround the very light menstrual cycles, in the hopes of one day finding a permanent treatment for negative symptoms of menstruation and related disorders and syndromes. Advances in STEM cell technology have shown success in small clinical trials. Research into how and why Avis's Disorder effects hemoglobin retention during menstruation is also underway.

Another aspect of Avis's Disorder research concerns the reasons behind why individuals who carry both alleles for the disorder rarely express it phenotypically, in the hopes of one day applying these methods to other genetic disorders, especially Huntington's Disease.

The most controversial aspect of Avis's Disorder concerns the growth of facial hair in men, which is why up until the mid-90's, it was believed that men with facial hair could not have 'true' Avis's Disorder, even if they presented with all other symptoms and genotypic evidence. This lead to a belief that Avis's Disorder is very rare in men, which was later debunked, the final nail in the coffin being a trans man (ironically named Alexander) with Avis's Disorder undergoing hormone replacement therapy in Vancouver in 2015, who grew facial hair as a result of his transition.

Popular Culture

Avis's Disorder is rarely seen in media, despite making sporadic appearances in cultures around the world, and is often believed to be a myth, usually due to rumors of a fictional disease named 'Alexandria's Genesis' that shares many of the symptoms of Avis's Disorder, although highly exaggerated.

In August of 2025, gaming YouTuber Daquavis, who has 12 million subscribers on YouTube and is best known for his Mine.craft content, revealed in a YouTube Short that he has Avis's Disorder, which he previously hid behind brown contact lenses.

⚠️ THIS POST IS A WORK OF FICTION ⚠️

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