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In first year of "Nelson & Murdock" Karen Page already encountered Fantastic Four (#2) and Namor (#7), as Matt and Foggy's clients. Then, she helped out Foggy during the trial of Ka-Zar (#12-14), while Matt was... well, trying not to get killed. it wasn't much of a big deal for Karen, but it definitely became some of highlights of her time in New York City, since as revisited in Daredevil: Yellow, she had a certain interest in forming-at-the-time superhero community.

Soon, Spider-Man broke into the law office, threatening Foggy. Recently, Spidey got into conflict with Hornhead's impersonator, and he falsely assumed that Foggy Nelson might be the Devil of Hell's Kitchen.

Karen was the one to bring some sense to Spidey, before he would actually harm anyone, as she also tried physically stop him. Although the first impression was rather messy, Karen deemed Spider-Man a trustworthy hero, who is falsely accused by Daily Bugle of being a threat and masked menace. Years later, Karen met Spidey's alter-ego due to mutual friendship with Ben Urich, which led to funny interaction and seemingly left them on friendly note.

Daredevil #17. Writer: Stan Lee

Fantastic Four liked the employees of law firm they hired very much. That's why Nelson, Murdock & Page attended various events organized by members of first Marvel's family, including Reed and Sue's wedding, where Karen helped to save the day by alerting other guests about change of plans, as Matt yet again excused himself by his blindness to dress up in Daredevil and fight the villains, who tried to ruin the wedding. All three also visit Alicia Master's (Ben Grimm's girlfriend) sculpture exhibit, as seen in Marvels #2.

Fantastic Four Annual #1. Writer: Stan Lee.

Off-panel, Karen developed a close enough friendship with Johnny Storm, AKA Human-Torch. While we never saw how that actually came to be, the bond was obviously a strong one, as Johnny decided to help Karen to look for missing Daredevil, and emotionally supported her all the way during this little journey they shared in search for Matt. She was comfortable with sharing her frustrations with him, and was compassionate to Johnny in return.

Daredevil #261. Writer: Ann Nocenti

Another unexpected friend of Karen is Natasha Romanoff AKA Black Widow. Their first meeting was under strange circumstances of some kinda of love triangle with Matt Murdock in-between (of course). Despite already announced marriage with Matt, Karen chose her acting career, letting Natasha to have Matt as romantic partner (#86).

Eventually, Natasha and Matt broke up, as Black Widow felt herself quite uncomfortable as a rebound girl, as Matt revealed himself to be not-over Karen. Nonetheless, she remained a close friend of Daredevil and came to help, when he asked to watch after Karen, as she was targeted by Bullseye in "Predator's Smile" novel. Their interaction was short, but sweet, as they joked about their connection to Devil of Hell's Kitchen.

When Karen opened law clinic in Hell's Kitchen, Natasha started working there as a volounteer in her free time from Avengers. In the same search of Matt that Karen had with Johnny Storm, Natasha also joined, alongside Karen protecting local kids from various dangers, as Hell unleashed on New York.

Daredevil #262. Writer: Ann Nocenti.

Speaking of Karen's acting career, in Hollywood, Karen met Johnny Blaze, who just recently became Ghost Rider. He was hired as a stuntman for TV show where Karen had a lead role.

In the course of Ghost Rider's stay in Los Angeles, he and Karen developed a romantic situationship. They kissed a few times and were planning to commit to an actual relationship, but then plot-twist came along with Karen's stunt-double revealed as brainwashed lost girlfriend/wife of Blaze, Roxxane Simpson. But since Roxxane, after some traumatic experience involving demons, wasn't sure in her past bond with Johnny, and even got in affair with another man, so Blaze kept his persuasions with Karen.

When Johnny was exposed as demonic Ghost Rider and he had to escape from California without saying goodbye.

Ghost Rider #13. Writer: Tony Isabella

After Johnny's escape, Karen was approached with role of lead girl in "The Incredible Hulk" TV series, based on actual ongoing-at-the-time show with Bill Bixby and Lou Ferrigno. Someone (again) put a million dollar bounty of Karen's head, since she was offered a huge milliion dollar deal (even reported by Variety magazine), and she was about to get hostage, only for Hulk himself to show up on set, as he wasn't pleased with upcoming show, and ruin villains plans as he got in another fight with an old frenemy, as well as Karen's aquiantance, Ben Grimm AKA The Thing.

On the same studio as Karen, by the way, Howard the Duck worked, but we have no idea if these two actually encountered each other or co-stared.

Fun-fact: "Incredible Hulk" show was the first on-screen appearance of Matt Murdock (Rex Smith), and Wilson Fisk (John Rhys-Davis). In "Trial of Incredible Hulk" (1989) there's also an original character, who is a mix of Foggy and Karen, Christa Klein, who was portrayed by Nancy Everhard. The same actress played Detective Samantha Leary in "The Punisher" film of the same year with Dolph Lundgren.

Marvel Two-In-One #46. Writer: Alan Kupperberg

During Karen's Hollywood career, past caught up with her. In her early years, as she struggled find a job in New York, she tried some modelling and made photos of unknown (presumabely, delicate) nature. Many years later, the photographer assistant Alfred Savin obtained the film to blackmail Karen. Without further ado, Karen decides to hire Power Man and Iron Fist, Heroes for Hire, to retrieve the film and money she paid, in order to make sure this footage will never see a light of day. Luke and Danny successfully accomplished the task.

Marvel Team-Up Annual #3. Writer: Roger Stern.

Also, worth mentioning, that Karen Page was, in fact, the first character of Daredevil mythos to be mentioned outside of comics. Even earlier than Daredevil himself.

In one of the episodes of Spider-Man cartoon, her name can be seen on a entrance of movie theather, promoting Karen's movie "Dinosaur Destroyer", where her co-star was Simon Williams, an Avenger known as Wonder Man. As the title imply, the movie might be set in Savage Land, where already mentioned Ka-Zar lived, as well as his wife Shanna the She-Devil. Who knows, maybe Simon and Karen portrayed Plunder couple in that movie?

Spider-Man and His Amazing Friends 1x02

Another "hire" situation occurred with... Well, not exactly a superhero, but an infamous S.H.I.E.L.D. agent John Garrett. It was an unfinished storyline, where Karen tried to expose a child pornography ring on the Internet, and law enforcements wouldn't listen to her. Karen decided to seek for private investigator, putting the ad about hiring, and Garrett, not longer after him being reactived as S.H.I.E.L.D. agent, showed up at Karen's doorstep to take on a job. The storyline was never quite resolved, so it's very little known about the aftermath of this interaction, especially considering John Garrett's rather dark reputation.

Daredevil #342. Writer: D. G. Chichester.

Another very vague and ambiguous interaction that never quite was seen, is that Doctor Strange was acquainted with Karen at some point. Stephen assumes that Matt finally married Karen and asks about her well-being. The problem was that Stephen didn't knew that by this point Karen has been dead for about a year, which leads Matt into another brooding episode of his.

...which is weird, considering that Strange attended Karen's funeral, alongside Fantastic Four, Spider-Man and Captain America. But who knows, all these multi-dimensional travels might have put some kind of amnesia on Stephen about recent years.

In fact, Karen and Strange were supposed to interact in a cancelled storyline by Frank Miller set right after "Born Again", which revolved about Satanic Panic. The script was canned due to being too dark and violent and scary.

Daredevil Vol. 2 #65. Writer: Brian Michael Bendis

Jumping back to much better times, when classic "Gang War" storyarc was happening, in order to defeat Kingpin and stop Spider-Man before he makes a terrible mistake, group of street-level heroes unite under Daredevil's leadership.

Karen participated in this little vigilante squad, being present at their briefing, meeting with Hero of Harlem... no, not Luke Cage. Sam Wilson, The Falcon, as he joined Daredevil to help him out. It seemed like Karen has befriended other guys in team prior to that meeting, including Melvin Potter and Francis Tork, friend of Sam.

Her interaction with Melvin trace back to the times when he was the villain Gladiator, and he terrorized Karen both in her "Daredevil" and "Ghost Rider" days, but a friendlier connection was built during already mentioned "Predator's Smile" novel.

Amazing Spider-Man #287. Writer: Jim Owsley

T'Challa also had a acquaintance with Karen Page, as Black Panther saved her from villain Starr Saxon. T'Challa and Karen never really meet in comics after that (despite frequent collaborations between Black Panther and Daredevil). But many years later, something rather interesting happens.

Daredevil #52. Writer: Stan Lee.

T'Challa created a backup plan for Machine that erases humanity's memory of superheroes (one that was used in Sentry's origin), basing artificial intelligence mainframe on Karen Page of all people. Or maybe that mainframe specifically took her form, adapting to Daredevil as the one to lead Marvel Knights to a victory.

Athought, comic is vague on whether it is really just AI or an actual ghost of Karen, in this storyline Karen had a chance to be part of Marvel Knights team, alongside Daredevil, Elektra, Punisher, Hulk and Black Panther, also meeting Sentry himself.

Marvel Knights 20th #2. Writer: Matthew Rosenberg

Speaking of Elektra, she and Karen saw each other naked. Ahem.

Elektra was aware of Karen for a while, and for the sake of drama, she attempted to convince Matt in breaking-up with Karen and pursue her instead, which Matt very indignantly rejected. Elektra was fuming with jealously for a bit, until Karen was arrested on charges of first-degree murder of policeman, actually staged by Mr. Fear in his scheme to destroy Daredevil's beliefs.

Elektra tried to help Matt with solving the case, but he (yet again) angrily refused an olive branch. That didn't stop Elektra tho, as she infiltrated Ryker's Island under the disguise of Nina. In that alter-ego, she looked after Karen in prison, as Mr. Fear tasked to murder Karen near the end of her trial.

Anyway, Elektra saved Karen right before guards struck her in showers, recognized her strenght and badass-ery, admited that Karen impressed her, despite initial spite Elektra held, and behind Karen's back she wished her and Matt a happily ever after.