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Despicable Me is a 2010 American animated comedy film produced by Universal Pictures and Illumination Entertainment, and distributed by Universal. The first feature film from Illumination, it was directed by Chris Renaud and Pierre Coffin and produced by Chris Meledandri, Janet Healy, and John Cohen, from a screenplay by Cinco Paul and Ken Daurio based on a story by Sergio Pablos. Despicable Me stars the voices of Steve Carell, Jason Segel, Russell Brand, Kristen Wiig, Miranda Cosgrove, Will Arnett, Danny McBride, Jack McBrayer, and Julie Andrews. The film follows Felonious Gru, a longtime supervillain who adopts three orphan girls to use as pawns in a villainous scheme but reluctantly develops an emotional attachment to them. Development of Despicable Me began when Pablos pitched the idea about a main character having villainous attributes and brought the concept to Meledandri following Illumination's foundation in 2007, with Paul and Daurio writing the script. The film was officially announced in 2008, with much of its creative team attached, while animation was provided by Paris-based studio Mac Guff (now Illumination Studios Paris). Pharrell Williams and Heitor Pereira composed the film's score, with original songs written and performed by the former. Despicable Me debuted at the Annecy International Animated Film Festival on June 9, 2010, and was theatrically released in the United States on July 9. The film received positive reviews from critics and earned $543.2 million worldwide, becoming the ninth-highest-grossing film of 2010. It was nominated for Best Animated Feature Film at the Golden Globe Awards, BAFTA Awards and Annie Awards and was also the winner for Favorite Animated Movie at the 2011 Kids' Choice Awards. Despicable Me began a successful franchise which includes six succeeding films.

Longtime supervillain Felonious Gru has his pride hurt when an unknown rival steals the Great Pyramid of Giza. Gru, his elderly assistant Dr. Nefario, and his army of Minions devise a plan to steal the Moon. Seeking financial assistance, Gru approaches Mr. Perkins, the director of the Bank of Evil, who orders Gru to procure a shrink ray. While at the bank, Gru meets Perkins' son, Vector, who was responsible for the Pyramid heist. Gru and two of his Minions obtain the shrink ray from a research base in Southeast Asia, only for Vector to ambush them and steal it for himself. After many failed attempts to infiltrate Vector's fortress, Gru notices three orphaned sisters, Margo, Edith, and Agnes, being allowed in to sell cookies to Vector. Gru adopts the girls under the guise of a dentist, using them to distract Vector while he reclaims the shrink ray. Afterwards, he tries to abandon the girls at an amusement park, but starts to bond with them, much to Nefario’s disapproval. Gru later shows Perkins the shrink ray through a video call, only to be rejected. Observing Gru's despair, the girls offer him their piggy bank, and the Minions pool their resources to fund the moon heist. Meanwhile, Perkins informs Vector of Gru's current possession of the shrink ray, prompting Vector to take action. Nefario calculates the day when the Moon is closest to Earth, which unfortunately coincides with the girls' upcoming ballet recital. Believing the girls are too much of a distraction to Gru, Nefario calls the orphanage's owner, Miss Hattie, to take the girls back. The next day, Gru successfully shrinks and steals the Moon. Hoping to make it to the recital on time, he rushes back to Earth, but finds that the recital has ended and that Vector has kidnapped the girls. Arriving at Vector's fortress, Gru surrenders the Moon to Vector, but Vector refuses to give back the girls. Enraged, Gru storms Vector's fortress, and Vector activates his escape aircraft. Meanwhile, Nefario and the Minions discover that the shrink ray's effects are temporary; the bigger an object's mass, the faster it reverts to its original size. Gru, Nefario, and the Minions manage to rescue the girls before the Moon returns to its normal size and launches itself into orbit, destroying Vector's aircraft and leaving him stranded. Gru reclaims custody of the girls, and they celebrate with a special ballet recital (making up for the one Gru missed), which turns into a dance party.